| 李阳,王登本,魏永梅,马俊彦,高颖,刘美芳,李建英,张惠民,鱼军.苏黄止咳胶囊联合阿斯美治疗感染后咳嗽疗效的Meta分析[J].实用中西医结合临床,2021,21(20): |
| 苏黄止咳胶囊联合阿斯美治疗感染后咳嗽疗效的Meta分析 |
| Meta-analysis of curative effect of Suhuang cough capsule combined with Asmeton in the treatment of post-infection cough |
| 投稿时间：2021-05-18 修订日期：2021-08-03 |
| DOI： |
| 中文关键词: 苏黄止咳胶囊 阿斯美 感染后咳嗽 Meta分析 |
| 英文关键词: Asmeton Suhuang cough capsule Post-infection cough Meta -analysis. |
| 基金项目:陕西省重点研发计划项目 西安市科技计划项目 |
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| 中文摘要: |
| 目的：通过Meta分析评价苏黄止咳胶囊联合阿斯美治疗感染后咳嗽的疗效及安全性。 方法：利用万方数据库（ WanFang Data ）、PubMed数据库、和中国知网（ CNKI ），检索有关苏黄止咳胶囊联合阿斯美对感染后咳嗽治疗疗效的临床随机对照试验（ RCT ）。对符合纳入标准的研究进行质量评价，使用Review Manager 5.4 软件进行荟萃分析。结果：最终有6项RCT符合纳入标准，总计747例患者。研究结果显示：苏黄止咳胶囊联合阿斯美的有效率高于对照组[RR=0.12，95%CI（ 0.06 ，0.24），P<0.00001]，差异有统计学意义；咳嗽症状评分低于对照组[MD=-0.61 ，95%CI（ -0.73 ，-0.50 ）P<0.00001]，差异有统计学意义；另外与对照组相比，实验组并未增加治疗后不良反应的发生，其中试验组与对照组恶心的不良反应发生率比较，无明显的统计学差异([RR=1.36， 95%CI（ 0.55 ，3.37 ），P=0.50] ；试验组与对照组心慌/心悸的不良反应发生率比较，无明显的统计学差异[RR=0.63，95%CI（ 0.16 ，2.44 ），P=0.50] ；试验组与对照组胃部不适不良反应发生率比较，无明显的统计学差异[RR=1.19，95%CI（ 0.38 ，3.75 ），P=0.77] ；试验组与对照组嗜睡的不良反应发生率比较，无明显的统计学差异[RR=0.79，95%CI（ 0.21 ，3.02 ），P=0.73]。结论：苏黄止咳胶囊联合阿斯美治疗感染后咳嗽有着较好的临床应用疗效，较低的不良反应发生率，临床上值得推广应用。 |
| 英文摘要: |
| Objective: To evaluate the efficacy and safety of Suhuang Zhike Capsule combined with Asmeton in the treatment of post-infection cough through Meta-analysis.Methods: Wanfang Data, PubMed database and CNKI were used to search for clinical randomized controlled trials (RCTs) on the efficacy of Suhuang cough capsule combined with Asmeton in the treatment of post-infection coughThe quality of the studies that met the inclusion criteria was assessed and a meta-analysis was performed using Review Manager 5.4 software.Results: Six RCTs ultimately met the inclusion criteria, with a total of 747 patients.The results indicated that the experimental group had high efficiency than control group [RR=0.12, 95%CI (0.06, 0.24), P<0.00001], with statistical significance.The cough symptom score was lower than the control group [MD=-0.61, 95%CI (-0.73, -0.50) P<0.00001], and there was a statistical difference.In addition, cotrasted with the control group, the experimental group did not increase the incidence of adverse reactions after treatment.And the incidence of adverse reactions of nausea was the same between the experimental group and the control group，with no statistical significance ([RR=1.36, 95%CI (0.55, 3.37), P=0.50].The incidence of adverse reactions of palpitation was the same between the experimental group and the control group，with no statistical significance [RR=0.63, 95%CI (0.16, 2.44), P=0.50].The incidence of adverse reactions to stomach discomfort was the same between the experimental group and the control group，with no statistical significance [RR=1.19, 95%CI (0.38, 3.75), P=0.77].The incidence of adverse reactions of somnolence was the same between the experimental group and the control group，with no statistical significance [RR=0.79, 95%CI (0.21, 3.02), P=0.73].Conclusion:Used Suhuang cough capsule combined with Asmeton to treat cough after infection, which has good curative effect and less adverse reactions, and is worthy to apply in clinical treatment. |
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