| 段凯军,李青.P504s、CK-h、p63蛋白、S-100蛋白与前列腺癌病理分级的关系[J].实用中西医结合临床,2021,21(4): |
| P504s、CK-h、p63蛋白、S-100蛋白与前列腺癌病理分级的关系 |
| Relationship between P504s, CK-h, p63 protein and S-100 protein and pathological grades of prostate cancer |
| 投稿时间：2021-01-26 修订日期：2021-01-26 |
| DOI： |
| 中文关键词: 前列腺癌 病理分级 α-甲酰基辅酶A-消旋酶 高分子量角蛋白 p63蛋白 S-100蛋白 |
| 英文关键词: Prostate cancer Pathological grades α-methylacy-CoAracemase Cytokeratin high molecular weight p63 protein S-100 protein |
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| 中文摘要: |
| 目的：探究前列腺癌病理分级与α-甲酰基辅酶A-消旋酶(P504s)、高分子量角蛋白(CK-h)、p63蛋白、S-100蛋白的关系。方法：选收集我院2017.1~2020.10期间前列腺穿刺活检标本,包括前列腺癌标本92例,纳入PCa组、良性前列腺增生标本80例,纳入BPH组。所有标本均行均行免疫组化检测P504s、CK-h、p63蛋白、S-100蛋白的表达,光镜下观察前列腺癌患者病理组织学形态,进行Gleason分级评分。比较P504s、CK-h、p63蛋白、S-100蛋白在PCa组、BPH组中的表达阳性率,及P504s、CK-h、p63蛋白、S-100蛋白在不同Gleason分级中的表达强度,采用Spearman相关性分析P504s、CK-h、p63蛋白、S-100蛋白表达强度与Gleason分级的相关性。结果：P504s在PCa组中表达阳性率高于BPH组,CK-h、p63蛋白、S-100蛋白在PCa组中表达阳性率低于BPH组(P均<0.05)；PCa组中Gleason评分≤7分者P504s表达强度低于Gleason评分>7分者(P均<0.05),CK-h、p63蛋白、S-100蛋白在PCa组不同Gleason分级中的表达强度差异无统计学意义(P均>0.05)；Spearman相关性分析结果显示,Gleason分级与P504s表达强度呈正相关性(r=0.632,P<0.05),与CK-h(r=0.212,P>0.05)、p63蛋白(r=0197,P>0.05)、S-100蛋白(r=0.244,P>0.05)表达强度无显著相关性。结论：P504s、CK-h、p63蛋白、S-100蛋白在前列腺的鉴别诊断中有重要的应用价值,P504s可作为评价前列腺癌病情与预后的重要参考指标。 |
| 英文摘要: |
| Objective: To explore the relationship between and pathological grades of prostate cancer α-methylacy-CoAracemase (P504s), cytokeratin high molecular weight (CK-h), p63 protein and S-100 protein. Methods: Prostate biopsy specimens were collected from January 2017 to October 2020 in our hospital, including 92 cases of prostate cancer specimens in PCa group and 80 cases of benign prostatic hyperplasia specimens in BPH group. All specimens underwent immunohistochemistry to detect the expressions of P504s, CK-h, p63 protein and S-100 protein. Histopathological morphology of patients with prostate cancer was observed under light microscope, and Gleason grading was scored. The positive expression rates of P504s, CK-h, p63 protein and S-100 protein between PCa group and BPH group and the expression intensities of P504s, CK-h, p63 protein and S-100 protein in different Gleason grades were compared. Spearman correlation analysis was used to analyze the correlation between expression intensities of P504s, CK-h, p63 protein and S-100 protein and Gleason grading. Results: The positive rate of P504s in PCa group was higher than that in BPH group while the positive rates of CK-h, p63 protein and S-100 protein in PCa group were lower than those in BPH group (all P<0.05). The expression intensity of P504s of patients with Gleason score ≤7 points in PCa group was lower than that of patients with Gleason score>7 points (all P<0.05), but there were no significant differences in the expression intensities of CK-h, p63 protein and S-100 protein in PCa group of patient with different Gleason grades (all P>0.05). Spearman correlation analysis showed that the Gleason grading was positively correlated with expression intensity of P504s (r=0.632, P<0.05), and was not significantly correlated with the expression intensities of CK-h (r=0.212, P>0.05), p63 protein (r=0197, P>0.05) and S-100 protein (r=0.244, P>0.05). Conclusion: P504s, CK-h, p63 protein and S-100 protein have important application value in the differential diagnosis of prostate. P504s can be used as an important reference index for evaluating the disease condition and prognosis of prostate cancer. |
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