| 葛平玉，郭银雪.祛瘀化痰二仙汤联合非布司他对高尿酸血症患者阴茎血流动力学及勃起功能障碍的影响[J].实用中西医结合临床,2020,20(14):1-3,8 |
| 祛瘀化痰二仙汤联合非布司他对高尿酸血症患者阴茎血流动力学及勃起功能障碍的影响 |
| Effects of Quyuhuatanerxian Decoction Combined with Febustat on Penile Hemodynamics and Erectile Dysfunction in Patients with Hyperuricemia |
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| DOI： |
| 中文关键词: 高尿酸血症 勃起功能障碍 祛瘀化痰二仙汤 非布司他 |
| 英文关键词: Hyperuricemia Erectile dysfunction Quyuhuatanerxian decoction Febustat |
| 基金项目:贵州省科技计划项目[编号：黔科合LH字（2016）7519号] |
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| 中文摘要: |
| 目的：观察祛瘀化痰二仙汤联合非布司他对高尿酸血症患者阴茎血流动力学及勃起功能障碍的影响。方法：选取2016年8月~2018年6月收治的高尿酸血症伴勃起功能障碍患者90例，采用信封法随机分为联合组和对照组各45例。对照组口服非布司他，联合组在对照组基础上加服祛瘀化痰二仙汤，两组均连续治疗12周。分析比较两组疗效，安全性和治疗前后阴茎血流动力学指标（双侧阴茎海绵体动脉收缩期最大流速、舒张末期流速、阴茎血管阻力指数、阴茎血流指数）水平、血管内皮功能指标（血浆内皮素-1、血浆一氧化氮）水平、国际阴茎勃起功能指数评分。结果：治疗前，两组国际阴茎勃起功能指数评分、阴茎血流动力学及血管内皮功能指标水平相比较，差异无统计学意义（P＞0.05）。与治疗前相比，两组治疗后阴茎血管阻力指数、阴茎血流指数、血浆内皮素-1水平均下降，而双侧阴茎海绵体动脉收缩期最大流速、舒张末期流速、血浆一氧化氮和国际阴茎勃起功能指数评分均提高（P＜0.05）。与对照组比较，联合组治疗有效率更高，治疗后的阴茎血管阻力指数、阴茎血流指数、血浆内皮素-1下降，双侧阴茎海绵体动脉收缩期最大流速、舒张末期流速、血浆一氧化氮和国际阴茎勃起功能指数评分均高于对照组（P＜0.05）。两组均无明显不良反应或并发症发生。结论：祛瘀化痰二仙汤联合非布司他可有效改善高尿酸血症患者血管内皮功能和阴茎动脉血流，从而有效治疗勃起功能障碍，且未增加不良反应。 |
| 英文摘要: |
| Objective: To observe the effect of Quyuhuatanerxian decoction combined with febustat on penile hemodynamics and erectile dysfunction in patients with hyperuricemia. Methods: From August 2016 to June 2018, 90 patients with hyperuricemia and erectile dysfunction were selected, and were randomly divided into combination group and control group with 45 cases in each group by the envelope method. The control group was given febustat orally, while the combination group was given Quyuhuatanerxian decoction on the basis of the control group, both groups were treated for 12 weeks. The efficacy, safety, penile hemodynamic indexes (peak systolic velocity and end diastolic velocity of bilaterd penile carernous arteries, penile vascular resistance index, penile blood flow index)levels, vascular endothelial function indexes (plasma endothelin-1, plasma nitric oxide) levels, and international penile erectile function index scores before and after treatment were analyzed and compared between the two groups. Results: Before treatment, there was no significant difference in international penile erectile function index scores, penile hemodynamics indexes and vascular endothelial function indexes between the two groups (P＞0.05). Compared with before treatment, the penile vascular resistance index, penile blood flow index and plasma endothelin-1 levels in the two groups were decreased, while the peak systolic velocity and end diastolic flow rate of bilaterd penile carernous ateries, plasma nitric oxide and international penile erectile function index scores of the two groups were increased (P＜0.05). Compared with the control group, the effective rate of the combination group was higher, the vascular resistance indexes, penile blood flow indexes and plasma endothelin-1 decreased after treatment, and the peak systolic velocity and end diastolic velocity of bilaterd penile carernous arteries, plasma nitric oxide and international penile erectile function index scores of the combination group were higher than those of the control group (P＜0.05). There were no obvious adverse reactions or complications in both groups. Conclusion: Quyuhuatanerxian decoction combined with febustat can effectively improve vascular endothelial function and penile arterial blood flow in patients with hyperuricemia, thus effectively treating erectile dysfunction without increasing adverse reactions. |
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