| 吴勇刚.胃蛋白酶原联合幽门螺杆菌抗体检测在早期胃癌筛查中的可靠性研究[J].实用中西医结合临床,2019,19(10):111-113 |
| 胃蛋白酶原联合幽门螺杆菌抗体检测在早期胃癌筛查中的可靠性研究 |
| Reliability Study of Pepsinogen Combined with Helicobacter Pylori Antibody Detection in Early Gastric Cancer Screening |
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| DOI： |
| 中文关键词: 早期胃癌筛查 ABC法 胃蛋白酶原检测 幽门螺杆菌抗体检测 |
| 英文关键词: Early gastric cancer screening ABC method Pepsinogen detection Helicobacter pylori antibody detection |
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| 中文摘要: |
| 目的：探讨运用“ABC法”联合检测胃蛋白酶原和幽门螺杆菌抗体在早期胃癌筛查中的临床价值。方法：回顾性分析符合要求的1 200例消化内科门诊患者的临床资料，按照胃癌高危人群的年龄分界将研究对象分为＜40岁和≥40岁两个群体；比较两个群体中胃癌风险分层各组例数和病理构成比是否有统计学差异。结果：＜40岁和≥40岁2个群体中C组和D组例数相比较，差异有统计学意义（P＜0.05），在≥40岁人群中被要求进一步胃镜检查的例数明显增多；在≥40岁人群中，B、C、D组中萎缩性胃炎、早期胃癌、进展期胃癌的发生率与A组和＜40岁人群相比较，差异有统计学意义（P＜0.05）。结论：运用“ABC法”进行不同群体的早期胃癌筛查，可以对筛查人群进行胃癌风险分层，减少了不必要的胃镜检查人数，避免了用单一的血清检测方法对早期胃癌的漏诊，提高了早期胃癌的检出率。 |
| 英文摘要: |
| Objective: To explore the clinical value of combined detection of pepsinogen and Helicobacter pylori antibodies in early gastric cancer screening by the "ABC method". Methods: Retrospectively analyzed the clinical data of 1 200 patients with digestive medicine outpatients who met the requirements, according to the age boundary of high-risk groups of gastric cancer, the subjects were divided into ＜40 years old group and ≥40 years old group. To compare the difference of gastric cancer risk stratification between the two groups in terms of number of cases and pathological constituent ratio. Results: There was a significant difference in the number of patients in group C and group D between those aged less than 40 years and those aged over 40 years (P＜0.05). The number of patient required further gastroscopy increased significantly in those aged over 40 years. Among those aged over 40 years, the incidence of atrophic gastritis, early gastric cancer and advanced gastric cancer in group B, C and D was higher than that in group A and ＜40 years old, There was significant difference between the two groups (P＜0.05). Conclusion: Using "ABC method" to screen early gastric cancer in different groups can stratify the risk of gastric cancer in screening population, reduce the number of unnecessary gastroscopic examinations, avoid the misdiagnosis of early gastric cancer with a single serum detection method, and improve the detection rate of early gastric cancer. |
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