| 吴勇刚.胃蛋白酶原联合幽门螺杆菌抗体检测在早期胃癌筛查中的可靠性研究[J].实用中西医结合临床,2019,19(11): |
| 胃蛋白酶原联合幽门螺杆菌抗体检测在早期胃癌筛查中的可靠性研究 |
| 胃蛋白酶原联合幽门螺杆菌抗体检测在早期胃癌筛查中的可靠性研究 |
| 投稿时间：2019-07-05 修订日期：2019-07-18 |
| DOI： |
| 中文关键词: 胃蛋白酶原 幽门螺杆菌抗体 早期胃癌 筛查 |
| 英文关键词: Pepsinogen Helicobacter pylori antibody Early gastric cancer Screening. |
| 基金项目: |
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| 中文摘要: |
| 目的：进一步探讨运用“ABC法”联合检测胃蛋白酶原和幽门螺杆菌抗体在早期胃癌筛查中的临床价值。方法：回顾性分析符合要求的1200例消化内科门诊患者的临床资料,按照胃癌高危人群的年龄分界,将研究对象分为＜40岁和≥40岁两个群体；比较两个群体中胃癌风险分层各组人数是否有统计学差异；比较ABCD风险分层组中病理构成比是否有统计学差异。结果：＜40岁和≥40岁两个群体中C组和D组人数比较有统计学意义(P＜0.05),在≥40岁人群中被要求进一步胃镜检查的人数明显增多；在≥40岁人群中,BCD组中萎缩性胃炎、早期胃癌、进展期胃癌的发生率和A组及＜40岁人群比较,差异有统计学意义(P＜0.05)。结论：运用“ABC法”进行人群的早期胃癌筛查,可以对筛查人群进行胃癌风险分层,减少了不必要的胃镜检查人数,避免了用单一的血清检测方法对早期胃癌的漏诊,提高早期胃癌的检出率。 |
| 英文摘要: |
| Objective: To further explore the clinical value of combined detection of pepsinogen and Helicobacter pylori antibodies in early gastric cancer screening using the "ABC method".Methods: The clinical data of 1200 patients with digestive medicine outpatients who met the requirements were retrospectively analyzed. According to the age boundary of high-risk groups of gastric cancer, the subjects were divided into two groups of <40 years old and ≥40 years old. The risk scores of gastric cancer in two groups were compared. Whether the number of people in each group was statistically different; whether the pathological composition ratio in the ABCD risk stratification group was statistically different.Results: The number of patients in group C and group D was significantly higher in the <40 years old and ≥40 years old group (P<0.05), and the number of people requiring further gastroscopy in the population aged 40 years or older was significantly increased; In the population, the incidence of atrophic gastritis, early gastric cancer, and advanced gastric cancer in the BCD group was significantly different from that in the A group and the <40 year old group (P<0.05).Conclusion: The use of "ABC method" for early gastric cancer screening in the population can stratify the risk of gastric cancer in the screening population, reduce the number of unnecessary gastroscopy, and avoid the missed diagnosis of early gastric cancer with a single serum test. The detection rate of early gastric cancer. |
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