| 周红辉,吴玉婷,赵恒,赵诗云.三七皂苷对SD大鼠血小板聚集及人凝血酶时间影响的实验研究[J].实用中西医结合临床,2019,19(10): |
| 三七皂苷对SD大鼠血小板聚集及人凝血酶时间影响的实验研究 |
| Experimental study on the effect of panax notoginseng saponins on platelet aggregation in SD rats and human thrombin time |
| 投稿时间：2019-06-28 修订日期：2019-09-04 |
| DOI： |
| 中文关键词: 三七皂苷 ADP 血小板聚集率 凝血酶时间 |
| 英文关键词: panax notoginseng saponins ADP platelet aggregation rate thrombin time |
| 基金项目:江西省卫生健康委中医药科研课题(编号：2016A121) |
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| 中文摘要: |
| 目的：探讨三七皂苷对人血体外及大鼠体内抗血小板聚集作用及其对人凝血酶时间的影响。方法：以二磷酸腺苷(ADP)作为诱导剂,测定三七皂苷在健康人血体外及大鼠体内给药对血小板5min之内的最大聚集率,并测定三七皂苷对健康人体外凝血酶时间。结果:三七皂苷在健康人体外血药浓度为0.5mg/ml,1.00 mg/ml时,与对照组比较,5min之内血小板最大聚集率显著性降低；SD大鼠体内给药剂量300、600mg/kg时,血小板聚集率与空白对照组比较,血小板5min之内最大聚集率显著性降低,抑制率与给药剂量呈正相关；三七皂苷给药组的健康人凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)与自身空白对照组比较,时间均有不同程度的延长,但无显著性差异。结论：本实验表明三七皂苷具有显著的体内、外抗血小板聚集作用,并通过抑制血小板聚集作用来实现或加强其活血祛瘀,通脉活络等功效。 |
| 英文摘要: |
| Objective: To investigate the anti-platelet aggregation effect of panax notoginseng saponins on human blood in vitro and rat in vivo and its effect on thrombin time.Methods: The adenosine diphosphate (ADP) was used as an inducer to determine the maximum aggregation rate of panax notoginseng saponins in rats and healthy human blood within 5 minutes after in vitro administration; and to determine the in vitro thrombin time of panax notoginseng saponins in healthy humans.Results: When the dose of panax notoginseng saponins was 300 and 600 mg/kg in SD rats, the maximum aggregation rate within 5 minutes of platelets was significantly decreased than that of the blank control group; The inhibition rate was positively correlated with the dose. Compared with the control group, the in vitro blood concentration of healthy people at 0.5 mg/ml and 1.00 mg/ml can significantly reduce the maximum aggregation rate of platelets within 5 minutes. The prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT) of healthy people were prolonged in varying degrees compared with the control group, but there was no significant difference.Conclusion: This experiment shows that panax notoginseng saponins has significant anti-platelet aggregation effect either in vitro or in vivo, and its effects of promoting blood circulation, stasis-removing, collaterals activating and so on are achieved or enhanced by inhibiting platelet aggregation. |
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