| 步晓筠,杨洁,刘建成,邵峰,毛小尹.银川地区临床血型不规则抗体检测和分析[J].实用中西医结合临床,2019,19(10): |
| 银川地区临床血型不规则抗体检测和分析 |
| Prevalence and Specificity of irregular RBC antibodies in Patients from Yinchuan |
| 投稿时间：2019-05-10 修订日期：2019-07-03 |
| DOI： |
| 中文关键词: 血型 不规则抗体 银川 |
| 英文关键词: blood group irregular antibody Yinchuan |
| 基金项目: |
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| 中文摘要: |
| 目的 通过对银川地区临床标本检测结果的分析,了解银川患者人群中各种不规则抗体的检出频率及分布特点。方法 应用盐水、抗球蛋白法、微柱凝胶法结合谱细胞确定不规则抗体的特异性。结果 从9244例临床标本中鉴定确认血型不规则抗体77例，其中Rh血型系统不规则抗体73例。60例不规则抗体来自孕妇或新生儿血样，抗D（42例）>抗E（10例）；其余17例来自各种疾病配血患者，抗E（9例）>抗D（1例）。结论 检出不规则抗体以Rh血型系统分布最多，孕妇与配血患者不规则抗体分布明显不同,妊娠及输血免疫刺激是Rh血型系统抗体产生的主要原因。 |
| 英文摘要: |
| Objective A retrospective study was performed to estimate the frequency and specificity of clinically significant irregular RBC antibodies of patients in Yinchuan. Methods Irregular antibody testing was carried out by brine, anti-human-globulin and microcolulmn gel test methods．Results A total of 77 samples containing specific irregular antibodies were found among 9244 patients in Yinchuan. Anti-Rh antibodies were identified in 73 patients．60 samples of irregular antibodies were identified from pregnant or neonatal patients, anti-D (42samples)>anti-E(10samples); other 17 samples of irregular antibodies were identified from pretransfusion cross-matching patients, anti-E (9samples)>anti-D(1samples). Conclusion The frequencies of Rh antibodies is significantly higher than irregular antibodies of other blood group. Of all the anti-Rh antibodies , anti-D is the most frequently identified in pregnant or neonatal patients, while anti-E is the most frequently identified in pretansfusion cross-matching patients. Alloimmunization by pregnancy and transfusion constitute the major causes of anti-Rh alloantibodies． |
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