| 马菲菲,张萍,王明超,李明.联合应用四妙丸水丸治疗急性痛风性关节炎的临床观察[J].实用中西医结合临床,2019,19(9): |
| 联合应用四妙丸水丸治疗急性痛风性关节炎的临床观察 |
| Clinical Observation on Treatment of Acute Gouty Arthritis with Combined Application of Simiao Pills |
| 投稿时间：2019-01-27 修订日期：2019-07-15 |
| DOI： |
| 中文关键词: 痛风性关节炎 四妙丸 疗效 复发 |
| 英文关键词: Acute Gouty Arthritis Si Miao Pills Celecoxib |
| 基金项目: |
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| 中文摘要: |
| 目的：观察联合应用四妙丸水丸治疗急性痛风性关节炎的临床疗效。方法：选取2017年9月~2018年5月山东省潍坊市人民医院风湿免疫科收治的急性痛风性关节炎男性患者98例，按照随机数字表法分为观察组47例和对照组51例。对照组给予塞来昔布治疗，观察组采用塞来昔布联合四妙丸水丸治疗，两组均治疗14 d，随访3个月。观察两组患者局部关节症状、体征改善程度及时间，近期复发率，血尿酸、血沉等生化指标的变化及药物不良反应发生情况。结果：本次研究共完成93例，观察组脱落病例2例，对照组脱落病例3例，脱落患者皆为失访。治疗前两组VAS评分、血沉（ESR）、血尿酸（UA）、白细胞（WBC）等比较均无差异（P＞0.05）；治疗后两组各时间点VAS评分均较治疗前降低（P＜0.05），治疗后观察组各时间点VAS评分均低于对照组，但差异无统计学意义（P＞0.05）；两组血尿酸、血沉均较治疗前下降（P＜0.05），观察组治疗后平均尿酸水平较对照组低，但差异无统计学意义（P＞0.05），两组治疗后血沉、白细胞计数比较差异均无统计学意义（P＞0.05）；治疗期间，观察组不良反应发生率较对照组低，但差异无统计学意义（P＞0.05）；随访3个月观察组复发率小于对照组（P＜0.05）。结论：与单纯塞来昔布治疗相比，四妙丸联合塞来昔布治疗急性痛风性关节炎无明显增效作用，但可减少近期复发率。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy of Simiao pills combined with western medicine in the treatment of acute gouty arthritis. Methods: A total of 98 Patients with acute gouty arthritis who were admittde to our hospital from September 2017 to May 2018 were randomly divided into two groups: 47 cases in the study group were treated with Simiao pills and celecoxib, and 51 cases in the control group were treated with celecoxib alone. All patients were treated for 14 days, and followed up for 3 months. The clinical effects of 2 groups, the symptoms of joint swelling and pain and the changes of blood biochemical indexes before and after treatment and recurrence rate within 3 months were compared, and the occurrence of adverse reactions was observed．Results: A total of 93 cases were completed in this study. There were 2 cases of shedding in the study group and 3 cases of shedding in the control group. All patients with shedding were lost to follow-up.There was no difference in VAS score, erythrocyte sedimentation rate (ESR), blood uric acid (UA), and white blood cell (WBC) between the two groups before treatment.The VAS, UA and ESR were reduced in 2 groups after treatment,and the difference was statistically significiant(P<0.05). The study group showed lower VAS and serum UA than the control group after the treatment ,but the difference was not statistically significiant (P＞0.05).There was no significant difference in ESR,WBC and the occurrence of adverse reactions between 2 groups after treatment (P＞0.05).The recurrence rate of the study group was lower than that of the control group (P<0.05). Conclusion: Simiao pills with western medicine does not show better curative effect on acute disease course than western medicine alone, but may reduce recent recurrence. |
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