| 黄争荣,赖义勤,王泳,叶艺东,陈乃杰.参附注射液联合剂量密集化疗治疗老年晚期胃癌的临床观察[J].实用中西医结合临床,2019,19(4): |
| 参附注射液联合剂量密集化疗治疗老年晚期胃癌的临床观察 |
| Clinical Observation of Shenfu Injection Combined with Dose-intensive Chemotherapy in the Treatment for Elderly Patients with Advanced Gastric Cancer |
| 投稿时间：2018-11-15 修订日期：2018-12-16 |
| DOI： |
| 中文关键词: 参附注射液 剂量密集化疗 老年人 胃癌 |
| 英文关键词: Shenfu Injection intensive-dose chemotherapy elderly people gastric cancer |
| 基金项目: |
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| 摘要点击次数: 1055 |
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| 中文摘要: |
| 目的：探讨参附注射液联合剂量密集化疗治疗老年晚期胃癌的临床疗效。方法：将70例老年晚期胃癌患者按数字随机表分为2组,对照组34例,治疗组36例,对照组采用常规剂量密集化疗,治疗组在此基础上联合参附注射液治疗。比较两组患者的近期疗效、Karnofsky评分、毒副反应等指标。结果：两组患者近期客观缓解率、疾病控制率比较无统计学意义(P >0.05),但治疗组Karnofsky评分改善显著高于对照组(P<0.05),同时治疗组毒副反应中乏力、恶心呕吐、骨髓抑制的发生率明显著低于对照组(P <0.05)。结论：参附注射液联合剂量密集化疗治疗老年晚期胃癌近期疗效肯定,且可降低化疗期间不良反应发生率,提高晚期胃癌老年患者的生活质量。 |
| 英文摘要: |
| Objective: To investigate the clinical efficacy of Shenfu injection combined with intensive dose chemotherapy in the treatment of elderly patients with advanced gastric cancer. Methods: 70 cases of elderly patients with advanced gastric cancer were divided into 2 groups according to the digital random table: the control group (n=34) and the treatment group (n=36). The control group was treated with conventional dose intensive chemotherapy and the treatment group was treated with Shenfu injection. The short-term efficacy, Karnofsky score and toxicity were compared between the two groups. Results: There was no significant difference in objective remission rate and disease control rate between the two groups (P>0.05), but the improvement of Karnofsky score in the treatment group was significantly higher than that in the control group (P < 0.05),and the incidence of fatigue, vomiting and Myelosuppression in the treatment group was significantly lower than that of the control group (P<0.05). Conclusion: Shenfu Injection adjuvant dose intensive chemotherapy is effective in the treatment of elderly patients with advanced gastric cancer, and it can reduce the incidence of adverse reactions during chemotherapy and improve the quality of life of the elderly patients. |
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