| 徐杰,宋旭,许永.血必净注射液对有机磷中毒并呼吸衰竭患者的临床效果[J].实用中西医结合临床,2018,18(11): |
| 血必净注射液对有机磷中毒并呼吸衰竭患者的临床效果 |
| Clinical effect of Xuebijing injection on patients with organophosphorus poisoning and respiratory failure |
| 投稿时间：2018-06-29 修订日期：2018-06-29 |
| DOI： |
| 中文关键词: 血必净注射液 有机磷中毒 呼吸衰竭 多重耐药菌 |
| 英文关键词: Xuebijing injection Organophosphorism Respiratory failure Multidrug-resistant bacteria |
| 基金项目: |
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| 中文摘要: |
| 【】 目的 探讨血必净注射液对于有机磷中毒并呼吸衰竭患者的临床效果。方法 将60例有机磷中毒并呼吸衰竭患者,随机分为对照组和治疗组,每组各30例。对照组接受一般综合治疗,治疗组在对照组基础上,静脉滴注血必净注射液40ml,一日两次,连续七天。治疗七天后统计各组患者的氧合指数(OI),白细胞(WBC),乳酸(Lac),记录两组患者APACHE II评分、胆碱酯酶(ChE)活性恢复时间、呼吸机上机时间、多种耐药菌(MDR)发生率等指标。结果 与对照组治疗后相比,治疗组氧合指数(OI)明显升高,WBC明显下降,APACHEⅡ、ChE恢复时间、呼吸机上机时间、多重耐药菌发生率均明显降低,〔OI(mmHg)：311.50±41.66比251.47±50.26,P＜0.05,WBC(×109/L )：4.41±1.5比6.96±2.4,P＜0.05,APACHE Ⅱ评分(分)：18.38±6.25比24.83±4.56,P＜0.05〕,治疗组胆碱酯酶(ChE)活性恢复时间,与对照组相比,明显缩短(d：7.37±2.07比11.66±1.86,P＜0.05),治疗组呼吸机上机时间较对照组明显缩短(d：10.28±3.19比15.61±4.07,P＜0.05),治疗组多重耐药菌发生率较对照组明显降低(d：14.31±3.07比19.64±4.82,P＜0.05)。结论 血必净注射液能够明显改善有机磷中毒并呼吸衰竭患者氧合指数、降低炎症反应、缩短胆碱酯酶活性恢复时间,减少多重耐药菌发生率,提高抢救成功率。 |
| 英文摘要: |
| Objective: To explore the clinical effect of Xuebijing injection on organophosphorus poisoning and respiratory failure patients. Methods: 60 organophosphorus poisoning and respiratory failure patients were randomly divided into control group and treatment group, with 30 patients in each group. The control group was given conventional comprehensive treatment. The treatment group was given 40 mL intravenous infusion of Xuebijing injection on the basis of the control group twice a day for 7 consecutive days. 7 days after statistics treatment group patients oxygenation index (OI), white blood cell (WBC), lactic acid (Lac), two groups of patients with APACHE II score, cholinesterase (ChE) activity recovery time, breathing machine on time, various indices such as the incidence of drug-resistant bacteria (MDR) were recorded. Results: Compared with control group after treatment, treatment group (oxygenation index (OI) increased significantly, the WBC decreased obviously, APACHE Ⅱ, ChE recovery time, time using breathing machine , incidence of multi-resistant bacteria were significantly lower, 〔OI (mmHg) : 311.50 + / - 41.66 than 251.47 + / - 50.26, P < 0.05, the WBC (x 109 / L) : 4.41 + / - 1.5 than 6.96 + / - 2.4, P < 0.05, APACHE Ⅱ score (points) : 18.38 + / - 6.25 than 24.83 + / - 4.56, P < 0.05〕, treatment group cholinesterase (ChE) activity recovery time was significantly shortened (d: 7.37 + / - 2.07 than 11.66 + / - 1.86, P < 0.05), the treatment group the time using breathing machine was significantly shortened (d: 10.28 + / - 3.19 than 15.61 + / - 4.07, P < 0.05), the treatment group than the control group significantly decreased incidence of multi-resistant bacteria (d: 14.31 + / - 3.07 than 19.64 + / - 4.82, P < 0.05). Conclusion: Xuebijing injection can improve oxygenation index in patients with organophosphorus poisoning and respiratory failure, reduce inflammation, decrease the incidence of multi-resistant bacteria, shorten the cholinesterase activity recovery time,and improve the success rate of rescue. |
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