| 蔡惠昭 黎春雷.5-氟尿嘧啶合地塞米松对翼状胬肉术后复发影响的临床研究[J].实用中西医结合临床,2018,18(4):9-11 |
| 5-氟尿嘧啶合地塞米松对翼状胬肉术后复发影响的临床研究 |
| The Clinical Study of 5-Fluorouracil Combined Dexamethasone on the Recurrence of Pterygium |
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| DOI： |
| 中文关键词: 翼状胬肉 5-氟尿嘧啶 地塞米松 |
| 英文关键词: Pterygium 5-Fluorouracil Dexamethasone |
| 基金项目:广东省茂名市科技计划项目（编号：20140331） |
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| 中文摘要: |
| 目的：探讨5-氟尿嘧啶联合地塞米松对翼状胬肉术后复发的防治效果。方法：选取2014年1月~2016年6月本院收治的初发性翼状胬肉患者170例（210眼），随机分为对照组A（5-氟尿嘧啶组）58例（70眼）、对照组B（妥布霉素地塞米松滴眼液组）56例（70眼）、观察组（5-氟尿嘧啶+地塞米松）56例（70眼）。对术后复发率、泪膜功能、患者舒适度及并发症进行比较分析。结果：观察组术后复发率明显低于对照组A和对照组B（?字2=3.905、4.763，均P＜0.05）；三组患者术前、术后3个月BUT和SIT之间比较差异不明显，均P＞0.05；三组患者术后1个月BUT和SIT之间比较差异显著（F检验值依次为4.834、3.827，均P＜0.05），其中观察组的BUT和SIT均明显高于对照组A和对照组B，均P＜0.05；术后1周、1个月三组患者舒适度评分之间比较具有统计学差异均P＜0.05，其中观察组术后1周、1个月舒适度评分显著低于对照组A和对照组B，均P＜0.05。术后3个月三组患者舒适度评分之间比较不具有统计学差异（P＞0.05）。结论：5-氟尿嘧啶联合地塞米松对翼状胬肉术后复发具有更有效的防治作用，对眼表无明显药物性损害，可为临床药物防治翼状胬肉术后复发提供新的治疗方法。 |
| 英文摘要: |
| Objective: To study the effect of 5-Fluorouracil combined Dexamethasone on the prevention and treatment of postoperative recurrence of pterygium. Methods: 170 patients(210 eyes) with primary pterygium were selected from Jan 2014 to Jun 2016 in the hospital, randomly divided into the control group A(5-Fluorouracil group) 58 cases(70 eyes), the control group B (Tobramycin Dexamethasone gutta group) 56 cases(70 eyes) and the observation group(5-Fluorouracil+ Dexamethasone group) 56 cases(70 eyes). Recorded and compared the postoperative recurrence rate, tear film function and patients comfort and complications. Results: The recurrence rate of the observation group after surgery was significantly lower than the control group A and control group B(The values of ?字2were 3.905,4.763 respectively, all P＜0.05); There was no significant difference in BUT and SIT between preoperative and postoperative 3 months in the three groups of patients (all P＞0.05); The three groups of patients after operation 1 month, SIT and BUT were significantly different(The values of F were 4.834, 3.827, all P＜0.05), the observation group's BUT, SIT were significantly higher than the control group A and control group B (both P＜0.05). After 1 week, 1 month comfort score of three groups were statistically significant (all P＜0.05). In the observation group, 1 week, 1 month comfort score of the observation group after the operation were significantly lower than that of the control group A and control group B (P＜0.05). 3 months after the operation compared with the three group's comfort score was not statistically significant (P＞0.05). Conclusion: 5-Fluorouracil combined Dexamethasone in the prevention and treatment of recurrence of pterygium after surgery can be more effective, with no obvious drugs damage on ocular surface, can provide a new way to prevent and control the recurrence of pterygium after operation. |
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