| Objective: To observe the clinical effect of truncation and torsion method of traditional chinese medicine in the treatment of hemorrhagic fever with renal syndrome (febrile phase), and to analyze the influence of the method on the changes of lymphocyte subsets. Methods: From November 2014 to June 2017, 80 cases of hemorrhagic fever with renal syndrome (HFRS) accompanied with fever (febrile phase) and mild symptoms and signs of TCM were selected as the research objects. They were randomly divided into western medicine group and integrative medicine group, with 40 cases in each group. The western medicine group was treated with routine western medicine, while the integrative medicine group was treated with traditional chinese medicine truncation and torsion method on the basis of the treatment of western medicine group. The scores of clinical symptoms and signs, severe prognosis, antipyretic score and time, bleeding, renal function recovery time and lymphocyte subgroup levels of the two groups after the treatment were compared. Results: When entering the group, there was no significant difference in the scores of TCM clinical symptoms and signs between the two groups, P＞0.05; and at the 3rd day, 6th day and 9th day, the scores of TCM clinical symptoms and signs in the integrative medicine group were significantly lower than those in the western medicine group, the difference was statistically significant, P＜0.05. At the 3rd day, the number of non-severe cases in the integrative medicine group was significantly more than that in the western medicine group, the difference was statistically significant, P＜0.05; at the 6th day and 9th day, there were no severe cases in the two groups, the difference was not statistically significant, P＞0.05. Before the treatment, there was no significant difference in antipyretic score between the two groups, P＞0.05. At the 3rd day, the antipyretic score of the integrative medicine group was significantly lower than that of the western medicine group, the differences were statistically significant, P＜0.05. At the 6th and 9th day, the antipyretic score of the two groups were 0, the difference was not statistically significant, P＞0.05. The antipyretic time of the integrative medicine group was significantly shorter than that of the western medicine group, the difference was statistically significant, P＜0.05. When entering the group, there was no significant difference in platelet level between the two groups, P＞0.05; but at the 3rd day, 6th day and 9th day, the platelet level of integrative medicine group was significantly higher than that of western medicine group, the difference was statistically significant, P＜0.05. When entering the group, there was no significant difference in urea nitrogen and creatinine levels between the two groups, P＞0.05, and the levels of urea nitrogen and creatinine in integrative medicine group were significantly lower than those in western medicine group at the 3rd day, 6th day and 9th day, the differences were statistically significant, P＜0.05. The recovery time of renal function in integrative medicine group was significantly shorter than that in western medicine group, the difference was statistically significant, P＜0.05. When entering the group, there was no significant difference in CD3, CD4, CD8 and CD4/CD8 between the two groups, the differences were not statistically significant, P＞0.05; there was no significant change in CD4 value of the western medicine group before and after treatment, the difference was not significant, P＞0.05; while the other indexes were improved significantly after the treatment, the differences were statistically significant, P＜0.05. And there was no significant change in CD3 of integrative medicine group before and after treatment, the difference was not significant, P＞0.05; and the other indexes were obviously improved after treatment, the differences were statistically significant, P＜0.05. Besides CD3, the improvement degree of other indexes in the group of integrative medicine were better than that in the western medicine group, the differences were statistically significant, P＜0.05. Conclusion: The clinical effect of traditional chinese medicine truncation and torsion method in the treatment of hemorrhagic fever with renal syndrome (febrile phase) is significant, and has a certain intervention effect on lymphocyte subsets. |
