| 邵雪松 郭晓玲.黄芪注射液治疗不稳定型心绞痛的临床研究[J].实用中西医结合临床,2018,18(1):3-5 |
| 黄芪注射液治疗不稳定型心绞痛的临床研究 |
| Clinical Study on Treatment of Unstable Angina Pectoris with Astragalus Injection |
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| DOI： |
| 中文关键词: 不稳定型心绞痛 黄芪注射液 基质金属蛋白酶9 基质金属蛋白酶组织抑制剂1 |
| 英文关键词: Unstable angina pectoris Astragalus injection Matrix metalloproteinase 9 Tissue inhibitor of matrix metalloproteinases 1 |
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| 中文摘要: |
| 目的：探讨黄芪注射液治疗不稳定型心绞痛的疗效及对患者基质金属蛋白酶9（MMP-9）、基质金属蛋白酶组织抑制剂1（TIMP-1）的水平影响。方法：选取本院心内科2015年4月~2016年10月收治的120例冠心病患者，随机分为中西医组和西医组，每组60例，两组患者均给予抗凝、调脂、缓解心绞痛等常规治疗措施，中西医组患者同时给予黄芪注射液，两组患者疗程均为2周。结果：治疗后中西医组患者的胸痛、胸闷、心悸、乏力评分均显著低于西医组患者（P＜0.05），中西医组患者的MMP-9值显著低于西医组患者（P＜0.05），TIMP-1值高于西医组患者（P＜0.05），中西医组患者的心电图疗效明显优于西医组患者（P＜0.05），中西医组患者的临床疗效明显优于西医组患者（P＜0.05）。结论：黄芪注射液联合常规疗法治疗冠心病的疗效确切，作用机制可能与降低血清MMP-9和提升TIMP-1水平有关。 |
| 英文摘要: |
| Objective: To investigate the curative effect of astragalus injection on the treatment of unstable angina pectoris and the effect of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1). Methods: 120 Patients with coronary heart disease who were enrolled in our hospital from April 2015 to October 2016 were randomly divided into the traditional chinese and western medicine group and the western medicine group, 60 cases in each group. Two groups were given routine treatment measures such as anticoagulantion, lipid regulation and relieving angina, patients in the traditional chinese and western medicine group were given astragalus injection at the same time, the treatment course of two groups were both 2 weeks. Results: The chest pain, chest tightness, palpitations and fatigue scores of the traditional chinese and western medicine group were significantly lower than those in the western medicine group after treatment (P＜0.05). The MMP-9 values of the traditional chinese and western medicine group were significantly lower than those in western medicine group (P＜0.05), and the TIMP-1 values were higher than those in the western medicine group (P＜0.05). The efficacy of ECG in the traditional chinese and western medicine group was significantly better than that in the western medicine group (P＜0.05), and the clinical efficacy of the traditional chinese and western medicine group was significantly better than that in the western medicine group (P＜0.05). Conclusion: The curative effect of astragalus injection combined with routine treatment on coronary heart disease is accurate. The mechanism may be related to lowering serum MMP-9 and improving the level of TIMP-1. |
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