| 渠甜甜.高龄老年高血压患者长时血压变异性与靶器官损害的关系[J].实用中西医结合临床,2017,17(8):118-120 |
| 高龄老年高血压患者长时血压变异性与靶器官损害的关系 |
| The Relationship Between Long-term Blood Pressure Variability and Target Organ Damage in Elderly Hypertensive Patients |
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| DOI： |
| 中文关键词: 原发老年高血压 长时血压变异性 靶器官损害 |
| 英文关键词: Essential hypertension Long-term blood pressure variability Target organ damage |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨高龄老年高血压患者长时血压变异性（Blood%Pressure%Variability，BPV）与靶器官损害的关系。方法：采用回
顾性病例分析研究，选取2015 年10 月~2016 年10 月于我中心住院的高龄老年高血压患者共98 例，连续7%d 测量血压，以收缩压
（SBP）值的标准差作为长时BPV 的量化指标，将研究对象分为两组：即BPV≥8.80%mm%Hg 组、BPV＜8.80%mm%Hg 组，收集患者的
临床资料进行分析，探讨高龄老年高血压患者长时BPV 与靶器官损害的关系。结果：长时BPV≥8.80%mm%Hg 组脑卒中患病率、尿
蛋白阳性率、SBP、左心室肥厚率、颈动脉内- 中膜厚度（IMT）均高于BPV＜8.80%mm%Hg 组（P ＜0.05）；BPV≥8.80%mm%Hg 组与
BPV＜8.80%mm%Hg 组在性别、年龄、糖尿病患病率、饮酒率、吸烟率、高血压病程、BMI、FBG、TG、TC、LDL-c、HDL-c 等指标方面比
较， 差异无统计学意义（P%＞0.05）； 对影响IMT 的各因素行多元线性回归分析显示，BPV、LDL-c、HDL-c 与IMT 显著相关（P＜
0.05）。结论：高龄老年高血压患者长时BPV 与靶器官损害紧密相关，具有很好的心脑血管病预测价值，应当重视对长时BPV 的评
估。 |
| 英文摘要: |
| Objective: To explore the relationship between long-term blood pressure variability (BPV) and target organ damage in
elderly hypertensive patients. Methods: 98 cases of elderly hypertensive patients hospitalized from October 2015 to October 2016 were
retrospectively studied. All patients's blood pressure were monitored for 7 consecutive days. The standard deviation of systolic blood
pressure (SBP) was considered as a quantitative indicator for long-term BPV. Patients were divided into two groups: BPV≥8.80 mm Hg
group and BPV＜8.80 mm Hg group. Clinical data were collected for the investigation of the association between long-time BPV with
target organ damage. Results: The prevalence of stroke, positive rate of urinary protein, SBP, positive rate of left ventricular hypertrophy
and IMT of long-term BPV≥8.80 mm Hg group were higher than those in BPV＜8.80 mm Hg group (P＜0.05). There was no statistically
significant difference between two groups in the indicators of sex, age, prevalence of diabetes, drinking, smoking, duration of
hypertension, BMI, FBG, TG, TC, LDL-c and HDL-c. Multiple linear regression analysis of all factors related to IMT showed that BPV,
LDL-c and HDL-c were significantly correlated with IMT (P ＜0.05). Conclusion: Long-term BPV in elderly hypertensive patients is
closely related to target organ damage and has good predictive value of cardiovascular and cerebrovascular diseases. More attention should
be attached on the assessment of long-term BPV. |
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