| 渠甜甜.高龄老年高血压患者长时血压变异性与靶器官损害的关系[J].实用中西医结合临床,2017,17(9): |
| 高龄老年高血压患者长时血压变异性与靶器官损害的关系 |
| The relationship between long-term blood pressure variability and target organ damage in the very elderly hypertensive patients QU Tian-tian.Department of General Practice,Changshou Street Community Health Service Center of Putuo District,Shanghai200060,China |
| 投稿时间：2017-06-10 修订日期：2017-06-13 |
| DOI： |
| 中文关键词: 高龄老年人 原发性高血压 长时血压变异性 靶器官损害 |
| 英文关键词: the very elderly essential hypertension long-term blood pressure variability target organ damage |
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| 中文摘要: |
| 目的 探讨高龄老年高血压患者长时血压变异性(blood pressure variability,BPV)与靶器官损害的关系。方法 采用回顾性病例分析研究,选取2015年10月份至2016年10月份于上海市普陀区长寿街道社区卫生服务中心住院的高龄老年高血压患者共98例,连续7天测量血压,以收缩压(SBP)值的标准差作为长时BPV的量化指标,将研究对象分为两组:即BPV≥8.80mmHg组、BPV〈8.80mmHg组,收集患者的临床资料进行分析,来探讨高龄老年高血压患者长时BPV与靶器官损害的关系。结果 长时BPV≥8.80mmHg组的研究对象脑卒中患病率、尿蛋白阳性率、SBP、左心室肥厚率、颈动脉内-中膜厚度(IMT)均高于BPV＜8.80mmHg组(P＜0.05)；BPV≥8.80mmHg组与BPV＜8.80mmHg组的研究对象在性别、年龄、糖尿病患病率、饮酒率、吸烟率、高血压病程、BMI、FBG、TG、TC、LDL-C、HDL-C等指标间比较,差异无统计学意义；对影响IMT的各因素行多元线性回归分析显示,BPV 、LDL-C、HDL-C与IMT显著相关(P＜0.05)。结论 高龄老年高血压患者长时BPV与靶器官损害紧密相关,具有很好的心脑血管病预测价值,应当重视长时BPV的评估。 |
| 英文摘要: |
| Objective This study aimed to explore the relationship between long-term blood pressure variability（BPV） and target organ damage in the very elderly hypertensive patients. Methods Ninty-eight cases of the very elderly hypertensive patients hospitalized in Changshou Street Community Health Service Center of Putuo District, Shanghai,from October 2015 to October 2016 ,were retrospectively studied. All patients’s blood pressure were monitored for 7 consecutive days. The standard deviation of systolic blood pressure (SBP) was considered as a quantitative indicator for long-term BPV.Patients were divided into two groups: BPV≥8.80mmHg group and BPV<8.80mmHg group. Clinical data were collected for the investigation of the association between long-time BPV with target organ damage in the very elderly hypertensive patients. Results The prevalence of stroke ,the positive rate of urinary protein, SBP, the positive rate of left ventricular hypertrophy and IMT in long-term BPV≥8.80mmHg group were higher than those in BPV <8.80mmHg group (P <0.05)；There was no statistically significant difference between BPV≥8.80mmHg group and BPV <8.80mmHg group in the indicators of sex,age,the prevalence of diabetes,drinking,smoking,duration of hypertension, BMI, FBG, TG, TC, LDL-C and HDL-C. Multiple linear regression analysis of all factors related to IMT showed that BPV,LDL-C and HDL-C were significantly correlated with IMT (P <0.05).Conclusion Long-term BPV in elderly hypertensive patients was closely related to target organ damage and had a good predictive value of cardiovascular and cerebrovascular diseases. More attention should be attached on the assessment of long-term BPV. |
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