| 徐丽芳,魏志鸿,王兆雷,徐洁,李鹏.130例不良反应报告分析及合理用药建议[J].实用中西医结合临床,2016,16(12): |
| 130例不良反应报告分析及合理用药建议 |
| Analysis of 130 cases of adverse drug reactions report and Suggestions for the rational use of drug |
| 投稿时间：2016-11-12 修订日期：2016-11-25 |
| DOI： |
| 中文关键词: 不良反应 合理用药 |
| 英文关键词: adverse drug reaction (ADR) rational use of drug |
| 基金项目: |
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| 中文摘要: |
| 目的：对130例临床药物不良反应报告进行回顾性分析,得出我院不良反应发生特点,并对合理用药进行建议,以减少我院不良反应发生率。方法：对130例不良反应从性别、年龄、给药途径、药物分类等方面进行统计分析。结果：我院不良反应特点是在老年人和儿童中发生率较高,分别为33.08%,16.15%；女性(66.15%)多于男性(33.84%)；发生不良反应最高的药物种类依次为抗菌药物(38.46%)、中成药(37.69%)及营养药物(6.92%),发生率较高品种为阿奇霉素、头孢呋辛、血塞通、痰热清、热毒宁,且儿童中抗菌药物不良反应发生率高(42.0%),育龄期妇女中成药不良反应发生率高(30.61%)。结论：在合理用药中,建议我院应重点监护儿童中抗菌药物使用,育龄期女性中成药使用,老年人中成药和抗菌药物使用,并对头孢呋辛、阿奇霉素、血塞通、热毒宁、痰热清几个品种建立重点监测制度,降低不良反应发生率。 |
| 英文摘要: |
| Objective: 130 cases of clinical reports of adverse drug reaction (ADR) were retrospectively analyzed, it is concluded that the characteristic of our reactions, and the rational drug use advice, in order to reduce our incidence of adverse reactions. Methods: 130 cases of adverse reactions were statistically analyzed from the gender, age, route of administration, drug classification and other aspects. Results: Adverse reaction in our hospital is characterized by a higher incidence in the elderly and children(33.08% and 16.15%); The rate of female patients (66.15%)was higher than that of male patients (33.84%). The highest drug typers of Adverse reactions successively were antibacterial drugs (38.46%), proprietary Chinese medicine (37.69%) and nutrition drugs (6.92%). The rates of azithromycin, cefuroxime, xuesaitong injection, shengmai injection, tanreqing injection, reduning injection were in the majority. The incidence of adverse drug reactions of antibacterial was high in children (42.0%), and incidence of adverse drug reactions of proprietary Chinese medicine was high in women of child-bearing age (30.61%). Conclusions: in the rational use of drug, it is suggested that the hospital should focus on monitoring of antimicrobial drug use in children, proprietary Chinese medicine use in childbearing age women, antimicrobial drug use and Chinese medicines use in the elderly. Set up a monitoring system for key to azithromycin, cefuroxime, xuesaitong injection, shengmai injection, tanreqing injection and reduning injection and reduce the incidence of adverse reactions. |
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