易路遥,熊蔚.高效液相色谱法测定马来酸多潘立酮片的含量[J].实用中西医结合临床,2016,16(10): |
高效液相色谱法测定马来酸多潘立酮片的含量 |
High performance liquid chromatography (HPLC) method for determining the content of Domperidone Maleate Tablets |
投稿时间:2016-10-16 修订日期:2016-11-02 |
DOI: |
中文关键词: 马来酸多潘立酮片 含量测定 高效液相色谱法 |
英文关键词: Domperidone Maleate Tablets Determination of content HPLC |
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中文摘要: |
目的:建立了高效液相色谱法测定马来酸多潘立酮片含量的方法。方法:使用十八烷基硅烷键合硅胶为填充剂的色谱柱,流动相为甲醇-0.5%乙酸铵(55:45),检测波长为285nm,流速1ml/min,柱温30℃。结果:马来酸多潘立酮在0.1294μg ~5.176μg之间呈良好线性关系,相关系数r2为0.99999;加标回收率在98.21%~101.73%之间。结论:本法准确、可靠,可用于马来酸多潘立酮片的质量控制。 |
英文摘要: |
Objective:To establish a method to determinate the content of Domperidone Maleate Tablets by High performance liquid chromatography (HPLC). Methods:Using C18 column, the mobile phase was methanol -0.5% ammonium acetate (55:45), the detection wavelength was 285nm,the flow rate was 1.0mL?min-1,temperature of column was set at 30℃.Results:Domperidone maleate in 0.1294μg ~5.176μg showed a good linear relationship, the correlation coefficient r2 was 0.99999; the rate of recovery was 98.21% ~ 101.73% of standard addition. Conclusion:This method is accurate and reliable, can be used for the quality control of Domperidone Maleate Tablets. |
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