| 石进峰.纤溶酶联合丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效观察[J].实用中西医结合临床,2016,16(10): |
| 纤溶酶联合丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效观察 |
| Clinical Observation of Fibrinolytic Enzyme Combined with Butylphthalide and Sodium Chloride Injection in Treating Acute Cerebral Infarction |
| 投稿时间：2016-10-06 修订日期：2016-10-31 |
| DOI： |
| 中文关键词: 脑梗死 纤溶酶 丁苯酞氯化钠注射液 血流变 微循环 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 目的 观察纤溶酶联合丁苯酞氯化钠注射液对溶栓时间窗外脑梗死患者血流变及微循环状态的影响和临床疗效。方法：按照随机数字表法将90例脑梗死患者随机分为观察组和对照组，每组45例。在基础治疗的基础上，对照组采用纤溶酶治疗，观察组采用纤溶酶联合丁苯酞氯化钠注射液。治疗前后观测大脑中动脉的峰流速(Vp)、平均流速(Vm)的变化情况，以及血流变、微循环状态、相关血液学观察指标和NIHSS评分变化。结果 治疗前血流变、微循环状态、相关血液观察指标和患者Vp、Vm均无显著差异，差异无统计学意义（P＞0.05）。治疗后，同组治疗前后差异有统计学意义(P＜0.05)；观察组血流变及微循环状态检测结果优于对照组，差异均具有统计学意义（P＜0.05）。两组患者Vp、Vm显著升高，NIHSS评分均有不同程度降低(P＜0.05)。两组患者的用药安全指标使用前后均在正常范围。结论 纤溶酶联合丁苯酞氯化钠注射液可有效改善脑梗死患者血流变、微循环状态、相关血液观察指标和血流动力学，提高急性脑梗死患者的临床疗效，有较高的临床应用价值。 |
| 英文摘要: |
| Objective To observe the effect of fibrinolytic enzyme combined with SBP injection on hemorrheology and microcirculation in patients with cerebral infarction after thrombolysis time. Methods According to the random number table method, 90 patients with cerebral infarction were randomly divided into the observation group and the control group, 45 cases in each group. On the basis of the basic treatment, the control group using fibrinolytic enzyme treatment, the observation group using fibrinolytic enzyme combined with sodium benzoate injection. The changes of peak velocity (Vp), mean flow velocity (Vm), blood rheology, microcirculation status, hematological parameters and NIHSS score were measured before and after treatment. Result There were no significant differences in blood rheology, microcirculation status, related blood parameters and Vp, Vm between the two groups (P>0.05). (P<0.05). The results of hemorrheology and microcirculation in the observation group were better than those in the control group (P<0.05), and the difference was statistically significant (P<0.05). The Vp, Vm and NIHSS scores of the two groups were significantly decreased (P<0.05). The safety indexes of both groups were in the normal range before and after use. Conclusion Fibrinolytic enzyme combined with DDP can improve the hemorheology, microcirculation status, hematological parameters and hemodynamics of patients with cerebral infarction, improve the clinical curative effect of patients with acute cerebral infarction, have a higher clinical Value. |
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