| 张念华.CT引导下植入125I放射性粒子联合化疗治疗结直肠癌肝转移的疗效分析[J].实用中西医结合临床,2016,16(10): |
| CT引导下植入125I放射性粒子联合化疗治疗结直肠癌肝转移的疗效分析 |
| Clinical observation of CT guided 125 I implantation combined with chemotherapy in treating liver metastasis of colorectal cancer |
| 投稿时间：2016-09-19 修订日期：2016-10-18 |
| DOI： |
| 中文关键词: 结直肠癌肝转移 化疗 125 I放射性粒子 近距离放射疗法 |
| 英文关键词: liver metastasis of colorectal cancer chemotherapy 125 I Radioactive particle Brachytherapy |
| 基金项目: |
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| 中文摘要: |
| 目的：评价CT引导下植入125 I放射性粒子联合化疗治疗结直肠癌肝转移的临床价值。方法：选取42例在我科接受化疗的结直肠癌肝转移患者,随机分为两组,其中研究组21例,在化疗的同时并植入125 I放射性粒子治疗,对照组21例,仅接受化疗。对所有患者按实体瘤疗效评价标准进行评价。结果：研究组完全缓解2例、部分缓解16例、稳定3例、进展0例,对照组完全缓解0例,部分缓解11例,稳定8例,进展2例。研究组客观反应率为85.7%(18/21),对照组客观反应率为52.4%(11/21),研究组的客观反应率较对照组明显升高(P=0.022)。治疗过程中并未发现严重不良事件,大多不良反应都是轻微、一过性的。两组在Ⅲ-IV度毒性反应方面并无明显差异。结论：CT引导下植入125 I放射性粒子联合化疗治疗结直肠癌肝转移在提高临床疗效的同时,不良反应并未增加。 |
| 英文摘要: |
| Objective To evaluate the clinical value of CT guided 125 I implantation combined with chemotherapy in treating liver metastasis of colorectal cancer. A total of 42 colorectal cancer patients with liver metastasis were received chemotherapy in our department. 21 patients were assigned to receive chemotherapy combined with CT guided radioactive 125 I implantation (experimental group), while another 21 patients received chemotherapy alone (control group). The effects were evaluated according to response evaluation criteria in solid tumors. Results Complete response (CR) was achieved in 2 of 21 experimental group patients, 16 had partial response (PR), 3 had stable disease (SD), and 0 had progressive disease (PD). While in control group, CR was seen in 0 patient, PR in 11 patients, SD in 8 patients, and PD in 2 patients. The objective reaction rate in experimental group was 85.7% (18/21), which was 52.4% (11/21) in control group. The objective reaction rate in experimental group was higher than that in control group (P=0.022). During the follow-up periods, most toxicity was low-grade and transient, and clinically significant adverse event was not observed. The grade 3-4 toxicities during treatments in experimental group and control group were no difference. Conclusion CT guided 125 I Implantation combined with thermotherapy is more effective than chemotherapy alone in colorectal cancer patients with liver metastasis, and the adverse reactions were not increased. |
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