| 罗红强,邓林强.两性霉素B联合利福平复方溶液治疗耳真菌病临床疗效研究[J].实用中西医结合临床,2016,16(9): |
| 两性霉素B联合利福平复方溶液治疗耳真菌病临床疗效研究 |
| The clinical effect of the combination of amphotericin B and rifampicin on otomycosis |
| 投稿时间：2016-08-30 修订日期：2016-08-30 |
| DOI： |
| 中文关键词: 耳真菌病 两性霉素B 利福平 |
| 英文关键词: Otomycosis Amphotericin B Rifampicin |
| 基金项目:江西省卫生厅科研课题（项目编号：20143003） |
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| 中文摘要: |
| 目的 观察两性霉素B联合利福平复方溶液治疗耳真菌病的临床疗效，进而探讨有效的治疗方法。方法 1、运用棋盘式微量液基稀释法测定两性霉素B联合利福平对白色念珠菌标准菌株（编号ATCC90028）的体外MIC值，在此基础上计算部分抑菌浓度指数（FIC）；依据FIC值判断两药联用是否有协同作用；2、经真菌培养及鉴定确定为耳真菌病60例患者中，根据临床症状与体征轻重的得分标准，随机分为三组,分别用两性霉素B、两性霉素B联合利福平复方溶液和3%水杨酸酒精滴耳液外耳道局部治疗一周，二周后，观察三组愈显率；并随访1年。结果 1、两药联用的FIC指数小于0.5； 2、三组愈显率比较，第1周:两性霉素B联合利福平复方溶液组愈显率最高，较其他两组有显著性差异( P <0. 05) ，第2周:两性霉素B和利福平组与两性霉素B组愈显率相比无显著性差异（P>0.05），以上两组分别与3%水杨酸酒精滴耳液组愈显率相比有显著性差异( P <0. 05)。随访一年，水杨酸酒精滴耳液组复发率比其它两组高，差异有统计学意义( P <0. 05)。结论 1、两性霉素B联合利福平对真菌有协同作用，2、两性霉素B联合利福平复方溶液外用制剂是治疗耳真菌病较理想的外用药物，且具有便于取材、配制简单、使用方便、起效快等优点，值得向基层医院推广。 |
| 英文摘要: |
| objective To estimate clinical effect of the combination of amphotericin B and rifampicin on otomycosis. Method Firstly , to measure the MIC of the combination of amphotericin B and rifampicin on candida albicans (ATCC90028) via the broth microdilution and calculated the fractional inhibitory concentration index (FIC), as well as to observe the synergistic effect of the drug combination. Secondly, 60 objects suffering from otomycosis were randomly divided into amphotericin B , the combination of amphotericin B and rifampicin and 3% alcohol salicylic acid treated groups according to the clinical symptoms and physical signs severity score standard. The clinical effective was abserved in indication time (7days and14days) and Followed up for one year .Results first, the FIC of the combination of the two drugs was less than 0.5; second, The clinical effective of combination of the two drugson otomycosis was evident than other groups at firt week (P < 0. 05); however, there was no significant difference between the combination of two drugs and the other groups at next week (P > 0.05). In addition , one year later , 3% salicylic acid ear drops by alcohol group have higher recurrence rate than other two groups (P < 0. 05). Conclusion clinical effect of the combination of amphotericin B and rifampicin on otomycosis was more abvious than the other two therapies ， and it maybe a novel therapeutic candidate against otomycosis due to efficiency ，cheap and convenience |
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