| 赵汝勤.阿奇霉素联合山莨菪碱治疗小儿支原体肺炎的临床疗效及免疫功能的影响[J].实用中西医结合临床,2016,16(8): |
| 阿奇霉素联合山莨菪碱治疗小儿支原体肺炎的临床疗效及免疫功能的影响 |
| The therapeutic effects and immune function of Azithromycin combined with Anisodamine in treatment of mycoplasma pneumonia in children |
| 投稿时间：2016-07-30 修订日期：2016-09-02 |
| DOI： |
| 中文关键词: 阿奇霉素 山莨菪碱 小儿支原体肺炎 免疫功能 临床疗效 |
| 英文关键词: Azithromycin anisodamine mycoplasma pneumonia immune function clinical curative effect |
| 基金项目: |
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| 中文摘要: |
| 【】目的 探讨阿奇霉素联合山莨菪碱治疗小儿支原体肺炎的临床疗效及其对免疫功能的影响。方法 选取2014年5月至2016年4月我院收治的小儿支原体肺炎患儿共140例。随机分为联合组和对照组,每组各70例,两组患者均予以化痰、止咳及对症支持治疗,同时予以阿奇霉素10mg/(kg.d)静滴7d。联合组在此基础上加用山莨菪碱注射液肺腧穴注射0.1～0.2mg/kg/d,持续治疗7d。对比两组患儿临床症状消失时间及住院时间、治疗前和治疗14天后的血浆免疫球蛋白和细胞炎症因子。结果 联合组的咳嗽缓解时间、退热时间、肺部啰音消失时间和住院天数显著低于对照组(P<0.05)。两组患儿治疗后的中性粒细胞百分比、血沉及CRP显著低于治疗前(P<0.05)；联合组治疗后的中性粒细胞百分比、血沉及CRP显著低于对照组(P<0.05)。 经过治疗后,两组患儿的血浆 IgA、 IgG、 IgM 均较治疗前显著升高( P＜0．05) , 且联合组和对照组之间有显著统计学差异( P＜0．05) 。结论 阿奇霉素联合山莨菪碱治疗小儿支原体肺炎可有效缩短病程,降低炎症反应,改善免疫功能,临床疗效可靠。 |
| 英文摘要: |
| Objective To explore the therapeutic effects and immune function of Azithromycin combined with Anisodamine in treatment of mycoplasma pneumonia in children. Methods 140 children with mycoplasma pneumoniaour treated in our hospital from May 2014 to April 2016 were selected and randomly divided into combined group and control group. Patients were to be phlegm, cough and symptomatic and supportive treatment, and given azithromycin 10mg / (kg.d) infusion 7d. On this basis, the combined group received lung acupoint injection of Anisodamine 0.1 ~ 0.2mg/kg/d and treated for 7d. The clinical symptoms and hospitalization time, the plasma immunoglobulin and inflammatory cytokines before and after treatment were compared in two groups of children . Results: The cough relief time, cooling time, pulmonary rales disappeared time and days of hospitalization in the combined group was significantly lower than the control group (P <0.05). The percentage of neutrophils, ESR and CRP in two groups of patients after treatment were significantly lower than before treatment (P <0.05). The percentage of neutrophils, ESR and CRP in the combined group after treatment was significantly lower than the control group (P <0.05 ). After treatment, the plasma levels of IgA, IgG and IgM were significantly higher in the two groups than before treatment (P < 0.05), and there was significant difference between the combined group and the control group (P < 0.05).Conclusion: Azithromycin combined with Anisodamine treatment of mycoplasma pneumonia in children can be effective to shorten the course, reduce inflammation, improve immune function, and reliable clinical efficacy. |
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