| 夏红梅 尹卫华 史国军 罗小瑾 聂春华.中医药联合化疗治疗老年肿瘤的Meta分析[J].实用中西医结合临床,2016,16(6):4-7,33 |
| 中医药联合化疗治疗老年肿瘤的Meta分析 |
| Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in the Treatment of elderly Patients with Cancer |
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| DOI： |
| 中文关键词: 老年肿瘤 中医药 化疗 Meta分析 |
| 英文关键词: Elderly patients with cancer Traditional chinese medicine Chemotherapy Meta-analysis |
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| 中文摘要: |
| 目的：评价中医药联合化疗治疗老年肿瘤患者的临床疗效及安全性。方法：检索中国期刊全文数据库、维普中文期刊数据库、万方学术期刊全文数据库等中文数据库中有关中医药联合化疗治疗老年肿瘤患者的随机对照实验，按照排除、纳入标准筛选后，使用Reman软件对数据进行Meta分析。结果：纳入21项RCT，共1 705例老年肿瘤患者，试验组877例，对照组828例。Meta分析结果显示，中医药联合化疗治疗老年肿瘤，在疾病控制率、提高生存质量、提高免疫功能、减轻骨髓抑制、减少胃肠道反应、减少肝肾功能损害等方面均优于单纯化疗。结论：中医药联合化疗治疗老年肿瘤患者的临床疗效及安全性优于单纯化疗，但由于本系统评价纳入研究的方法学质量较低，尚需纳入更多设计合理、执行严格的多中心大样本且随访时间足够长的随机对照试验，以验证其疗效及安全性。 |
| 英文摘要: |
| Objective: To evaluate the clinical efficacy and safety of traditional chinese medicine (TCM) combined with chemotherapy in the treatment of elderly patients with cancer. Methods: Searched the chinese journal full text database, VIP chinese periodical database, Wanfang academic periodical full text database of chinese database about the randomized controlled trial(RCT) of traditional chinese medicine combined with chemotherapy treatment in elderly patients with cancers. After the preparation by screening on the inclusion criteria and exclusion criteria,the data was made the Meta analysis by Reman software. Results: 21 RCTs involving 1 705 cases were included, with 877 cases in the experimental group of traditional chinese medicine in combination with chemotherapy and the 828 cases in the control group of chemotherapy. Meta analysis results showed that the experimental group was superior to the control group in disease control rate, enhancing the quality of life and immune function, reducing the myelosuppression, gastrointestinal reaction and the damage to liver and kidney function. Conclusion: Traditional chinese medicine plus chemotherapy is more effective and safe in comparison with chemotherapy in elderly patients with cancer. But the quality of studies is low; more large-scale multi-center randomized trials are needed. |
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