| 贺青军 陈伟强 罗智敏 庞建萍 欧惠珍 刘照宏.益气舒心丸对冠心病PCI术后患者左心室舒张功能的影响和机制研究[J].实用中西医结合临床,2016,16(6):1-3,10 |
| 益气舒心丸对冠心病PCI术后患者左心室舒张功能的影响和机制研究 |
| Effect and Mechanism of Yiqishuxin Pill on Left Ventricular Diastolic Function in Patients with Coronary Heart Disease After PCI |
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| DOI： |
| 中文关键词: PCI术后 气虚证 血瘀证 益气舒心丸 左心室舒张功能 一氧化氮、hs-CRP、内皮素-1 |
| 英文关键词: After PCI Qi deficiency Blood stasis Yiqishuxin pill Left ventricular diastolic function Nitric oxide Endothelin 1 High sensitive C-Reactive Protein |
| 基金项目:广东省佛山市2014年科技局立项攻关课题（编号：2014AB00334） |
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| 中文摘要: |
| 目的：观察益气舒心丸对冠心病PCI术后患者左心室舒张功能的影响并探讨相关机制。方法：将符合诊断标准的102例冠心病患者随机分为两组。对照组50例予西医常规治疗，不加用任何具有益气或活血作用的中药或中成药；治疗组52例在西医治疗基础上，加用益气舒心丸，治疗6个月。测定治疗前后气虚证、血瘀证计分和一氧化氮（NO）、hs-CRP、内皮素-1（ET-1）等指标的变化。同时，治疗前后行彩色多谱勒超声心动图测定左心室舒张功能等指标变化。结果：治疗组的气虚证、血瘀证计分较治疗前明显降低，优于对照组（P＜0.05）；治疗组的ET-1、hs-CRP较治疗前明显降低，NO较治疗前升高，均优于对照组（P＜0.05）；治疗组的超声心动图测定左心室舒张功能等指标较对照组改善明显，差异有显著统计学意义（P＜0.05）。结论：益气舒心丸可改善冠心病PCI术后患者气虚血瘀状态，改善血管内皮功能，增加舒张期心肌顺应性，从而改善左心室舒张功能。 |
| 英文摘要: |
| Objective: Observe the effect and mechanism of Yiqishuxin pill on left ventricular diastolic function in patients with coronary heart disease after PCI. Method: 102 Cases of ACS were randomly divided into 2 groups according to the diagnostic criteria. The control group (50 cases) received routine treatment of western medicine, without using any chinese medicine with supplementing Qi and activating blood circulation effect. The treatment group (52 cases) on the base of western medicine treatment, plus Yiqishuxin pill, 6 months for a course of treatment. Before and after the treatment, the integral of Qi deficiency and blood stasis syndrome, nitric oxide (NO), hs CRP, endothelin-1 (ET-1) were determined. At the same time, left ventricular diastolic function was tested by color Doppler echocardiography. Result: The integral of Qi deficiency and blood stasis syndrome of the treatment group decreased significantly than before treatment, better than the control group (P＜0.05); the ET-1, hs-CRP of the treatment group lower significantly than before treatment, the NO of the treatmengt group increased significantly than before treatment, and better than the control group (P＜0.05); the left ventricular diastolic function of the treatment group were improved significantly compared with the control group, the difference was statistical significant (P＜0.05). Conclusion: Yiqishuxin pill can improve the Qi and blood stasis state, endothelial function, diastolic myocardial compliance of the coronary heart disease patients after PCI, thereby improving left ventricular diastolic function. |
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