卡托普利联合氨氯地平对冠心病并高血压患者的疗效及安全性观察

张海东; 苏妤

文章摘要

张海东苏妤.卡托普利联合氨氯地平对冠心病并高血压患者的疗效及安全性观察[J].实用中西医结合临床,2016,16(3):7-8,38

卡托普利联合氨氯地平对冠心病并高血压患者的疗效及安全性观察

Clinical Efficacy and Safety of Captopril Combined with Amlodipine in the Treatment of Patients with Coronary Heart Disease and Hypertension

DOI：

中文关键词: 冠心病并高血压卡托普利氨氯地平临床疗效安全性

英文关键词: Coronary heart disease and hypertension Captopril Amlodipine Clinical efficacy Safety

基金项目:

作者	单位
张海东苏妤	新疆乌鲁木齐武警边防总队医院内科；新疆乌鲁木齐石油总医院内科

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中文摘要:

目的：探析卡托普利联合氨氯地平对冠心病并高血压患者的疗效及安全性。方法：选取2014年1月~2015年10月来我院就诊的冠心病并高血压患者80例，随机分为观察组与对照组，每组40例，对照组给予尼群地平、硝酸异山梨酯联合双氢克尿噻进行治疗；观察组给予卡托普利联合氨氯地平进行治疗，分析两组的临床疗效。结果：治疗后，观察组患者的舒张压与收缩压分别是（73.64±1.35） mm Hg、（129.90±3.10） mm Hg，对照组患者的分别是（89.35±3.88） mm Hg、（140.98±4.83） mm Hg，差异有统计学意义，P＜0.05；观察组的冠心病治疗总有效率是92.5%，对照组的是75.0%，差异有统计学意义，P＜0.05；观察组患者的心电图改善率是87.5%，对照组的是62.5%，差异有统计学意义，P＜0.01。结论：卡托普利联合氨氯地平对冠心病并高血压患者的疗效较为理想，且安全性良好，能够有效缓解患者的临床症状。

英文摘要:

Objective: To study and analysis the efficacy and safety of captopril combined with amlodipine in the treatment of patients with coronary heart disease and hypertension. Methods: From January 2014 to December 2015, 80 patients with coronary heart disease and hypertension in our hospital were randomly divided into control group and observation group, each group with 40 patients. The control group was treated with nitrendipine, isosorbide dinitrate combined with dihydro chlorothiazide; while the observation group was given captopril combined with amlodipine. After the treatment, the clinical efficacies of the two groups were statistically analyzed. Results: After the treatment, the diastolic blood pressure and systolic blood pressure of the patients in the observation group were (73.64±1.35) mm Hg and (129.90±3.10) mm Hg respectively, that in the control group were (89.35±3.88) mm Hg and (140.98±4.83) mm Hg, the difference was statistically significant, P＜0.05; the observation group’s coronary heart disease treatment effective rate was 92.5%, while the control group’s was 75.0%, the difference was statistically significant, P＜0.05; the observation group’s ECG improvement rate was 87.5%, while the control group’s was 62.5%, the difference was statistically significant, P＜0.05. Conclusion: Captopril combined with amlodipine in the treatment of patients with coronary heart disease and hypertension is more effective, and with good safety, it can effectively alleviate the clinical symptoms of patients.

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