| 李世灵 蔡扬 于燕妮.口腔鳞状细胞癌中PLK1蛋白表达与中心体扩增[J].实用中西医结合临床,2016,16(3):4-6,26 |
| 口腔鳞状细胞癌中PLK1蛋白表达与中心体扩增 |
| PLK1 Protein Expression and Centrosome Amplification in Oral Squamous Cell Carcinoma |
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| DOI： |
| 中文关键词: 口腔鳞状细胞癌 保罗样激酶-1 ?酌-微管蛋白 中心体扩增 |
| 英文关键词: Oral squamous cell carcinomas Polo-like kinase 1 (PLK1) ?酌-Tubulin protein Centrosome amplification |
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| 中文摘要: |
| 目的：探讨口腔鳞状细胞癌（Oral Squamous Cell Carcinoma，OSCC）中保罗样激酶-1（Polo-Like Kinase 1，PLK1）蛋白表达与中心体扩增之间的相关性。方法：采用免疫组化SABC法检测10例正常口腔黏膜和47例OSCC中PLK1蛋白和?酌-微管蛋白的表达情况，并分析两者之间的相关性。结果：PLK1蛋白和?酌-微管蛋白在正常口腔黏膜组和OSCC组中的阳性表达率分别为0.0%（0/10）、70.2%（33/47）和0.0%（0/10）、76.6%（36/47），PLK1蛋白和?酌-微管蛋白表达在正常口腔黏膜组和OSCC组之间的差异均具有统计学意义，P＜0.05；Spearman相关分析显示，OSCC组织中PLK1蛋白与?酌-微管蛋白表达之间正相关，r=0.305，P＜0.05。结论：PLK1蛋白过表达可能是中心体扩增的潜在机制之一，PLK1蛋白过表达导致中心体扩增及细胞恶性增殖在OSCC发生中可能起一定的作用。 |
| 英文摘要: |
| Objective: To study the correlation between polo-like kinase 1 protein expression and centrosome amplification in oral squamous cell carcinoma. Methods: The expressions of PLK1 and ?酌-tubulin proteins in 10 cases of normal oral mucosa and 47 cases of oral squamous cell carcinoma were investigated by SABC method, and analyzed the correlation between them. Results: Rate of positive expression of Plk1 protein and ?酌-tubulin in normal oral mucosa group and OSCC group were 0% (0/10), 70.2% (33/47) and 0% (0/10), 76.6% (36/47) respectively, and differences of Plk1 protein and ?酌-tubulin expression between OSCC group and normal oral mucosa group were statistically significant, P＜0.05. Spearman correlation analysis showed that the expression of PLK1 protein in OSCC tissue was positively correlated with the expression of gamma tubulin, r=0.305, P＜0.05. Conclusion: Over-expression of PLK1 protein may be a potential mechanism of centrosome amplification, while PLK1 protein leads to centrosome amplification and cell proliferation may play a role in the occurrence of OSCC expression. |
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