| 庄媛媛,马培,林明宝,侯琦.JAK激酶抑制剂在类风湿性关节炎治疗中的研究进展[J].实用中西医结合临床,2016,16(1): |
| JAK激酶抑制剂在类风湿性关节炎治疗中的研究进展 |
| Advance in research of JAK kinase inhibitors fortreating rheumatoid arthritis |
| 投稿时间：2016-02-05 修订日期：2016-02-22 |
| DOI： |
| 中文关键词: JAK激酶 类风湿性关节炎 JAK抑制剂 |
| 英文关键词: JAK kinase rheumatoid arthritis JAK inhibitor |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目）;国家科技攻关计划 |
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| 中文摘要: |
| 非受体酪氨酸激酶-JAK激酶(Janus kinases)通过与细胞内信号转导及转录激活蛋白(signal transducers and activators of transcription,STAT)之间的相互作用,在炎症因子调控的细胞内受体信号通路中发挥重要的调控功能,参与调控细胞内转录、增殖、凋亡及发育等多种生物学过程。目前,JAK/STAT信号通路异常活化对类风湿性关节炎疾病进程的影响已倍受关注,其与关节组织中淋巴细胞、粒细胞等多种相关炎症细胞的功能失调相关。JAK 可能作为治疗类风湿性关节炎的新靶点在临床应用中发挥重要作用。为此,本文简要论述JAK激酶在类风湿性关节炎中的作用机制以及相关抑制剂的研究进展,以期为进一步创新药物的发现寻找思路。 |
| 英文摘要: |
| Non-receptor tyrosine kinase-JAK kinases play important regulating function in the intracellular signaling pathways regulated by inflammatory factors, and involve in many kinds of biological processes such as transcription, proliferation, apoptosis and development of cells by the interaction of signal transducers and activators of transcription (STAT).Recently, the abnormal activation of JAK/STAT signaling pathway which associates with the dysfunction of lymphocytes, neutrophils and other inflammatory cells for the process of rheumatoid arthritis has been paid close attention. JAK may be a new target for the clinical treatment of rheumatoid arthritis. For this reason, this paper discusses the role of JAK kinases in the mechanism of rheumatoid arthritis and the research progress of relevant inhibitors, in order to seeking new thinking for further innovation drug discovery. |
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