| 韦刚 李海强 罗昭芳.温补脾肾法联合康复新液灌肠对溃疡性结肠炎的疗效观察及对炎症因子的影响[J].实用中西医结合临床,2016,16(1):10-13 |
| 温补脾肾法联合康复新液灌肠对溃疡性结肠炎的疗效观察及对炎症因子的影响 |
| Clinical Research of Warming and Tonifying the Spleen and Kidney Combined with Kangfuxin Enema in Treatment of Ulcerative Colitis and Its Influences on Inflammatory Cytokines |
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| DOI： |
| 中文关键词: 溃疡性结肠炎 温补脾肾法 康复新液灌肠 临床疗效 炎症因子 |
| 英文关键词: Ulcerative colitis Kangfuxin enema Warming and tonifying the spleen and kidney Clinical effect Inflammatory cytokine |
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| 中文摘要: |
| 目的：观察温补脾肾法联合康复新液灌肠治疗溃疡性结肠炎（UC）的临床疗效及对炎症因子血清肿瘤坏死因子（TNF-?琢）、白细胞介素8（IL-8）、白细胞介素10（IL-10）的影响。方法：将60例UC患者随机分为对照组和治疗组，每组30例，对照组给予柳氮磺吡啶肠溶片口服治疗，治疗组在对照组的治疗基础上加用温补脾肾法联合康复新液保留灌肠治疗，15 d为1个疗程，4个疗程后，比较两组患者的中医证候积分，肠镜下黏膜评分和IL-8、IL-10、TNF-?琢的变化。结果：治疗后，治疗组有效率93.33%，对照组有效率66.67%，治疗组疗效优于对照组，差异有统计学意义，P＜0.05；治疗前后两组组内及治疗后两组肠镜下黏膜评分比较，差异均有统计学意义，P＜0.05；两组治疗前后中医症状积分比较，差异有统计学意义，P＜0.05；两组的IL-8、TNF-?琢水平明显下降，IL-10水平明显升高，差异有统计学意义，P＜0.05。结论：温补脾肾法联合康复新液灌肠治疗溃疡性结肠炎疗效确切，能有效抑制与UC相关的炎性反应。 |
| 英文摘要: |
| Objective: To observe the clinical effect of warming and tonifying the spleen and kidney combined with Kangfuxin enema in the treatment of patients with ulcerative colitis (UC) and its influences on Inflammatory cytokines like TNF-?琢, IL-8 and IL-10. Methods: 60 Cases of ulcerative colitis were randomly divided into treatment group and control group with 30 cases each, the control group was given Sulfasalazine capsule oral, and the treatment group was given warming and tonifying the spleen and kidney combined with Kangfuxin enema on the basis treatment of the control group. 15 days for one course, after 4 courses, compared the TCM symptoms scores, endoscopic mucosal scores and the changes of TNF-?琢, IL-8 and IL-10 of the two groups. Results: After the treatment, the effective rate of treatment group was 93.33%, the effective rate of control group was 66.67%, the effective rate of treatment group was better than the control group, the difference was statistically significant, P<0.05. Compared the endoscopic mucosal scores in each group before and after the treatment and in two groups after the treatment, the differences were statistically significant, P<0.05. Compared the TCM symptoms scores in two groups before and after the treatment, the differences were statistically significant, P<0.05. The levels of IL-8 and TNF-?琢 were significantly decreased, and the level of IL-10 was significantly increased, the difference was statistically significant, P<0.05. Conclusion: The clinical effect of warming and tonifying the spleen and kidney combined with Kangfuxin enema in the treatment of patients with ulcerative colitis (UC) is exact, and it can inhibit the inflammatory response in UC. |
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