| 黄翠玲.那格列奈和阿卡波糖治疗2型糖尿病的临床疗效比较黄翠玲 北京市中西医结合医院内分泌科 100039[J].实用中西医结合临床,2016,16(1): |
| 那格列奈和阿卡波糖治疗2型糖尿病的临床疗效比较黄翠玲 北京市中西医结合医院内分泌科 100039 |
| The Glenn nye and acarbose clinical curative effect comparison cui-ling huang for the treatment of type 2 diabetes The cooperation of Chinese and western medicine hospital endocrinology 100039 of Beijing |
| 投稿时间：2015-08-20 修订日期：2015-09-14 |
| DOI： |
| 中文关键词: 【关键词】2型糖尿病 阿卡波糖 那格列奈 临床疗效 |
| 英文关键词: 【 key words 】 in type 2 diabetes Acarbose. The Glenn nye Clinical curative effect |
| 基金项目: |
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| 中文摘要: |
| 【】目的：观察那格列奈和阿卡波糖治疗2型糖尿病的临床疗效。方法：将我院内分泌科门诊采用饮食控制和运动治疗不满意的2型糖尿病患者64例,随机分为实验组(那格列奈组)和对照组(阿卡波糖组)各32例,进行为期12 周的临床治疗。结果：两组患者空腹血糖(FBG),餐后2小时血糖(2hPG)和糖化血红蛋白(HbA1c)均较治疗前有明显下降(P<0.05),但两组间比较差异无统计学意义(P>0.05)；对体重的影响方面,阿卡波糖降低体重的效果明显强于那格列奈,二者差异具有统计学(P<0.05)；阿卡波糖组的胃肠道不适明显高于那格列奈组(是那格列奈组的10倍)；那格列奈与阿卡波糖相比,虽然低血糖发生的风险在数值上有所增加,但差异无统计学意义。结论：那格列奈和阿卡波糖均有明显降低空腹和餐后血糖以及HbA1c的作用；与阿卡波糖相比,那格列奈引起胃肠道不适要少,依从性、耐受性和安全性要好。 |
| 英文摘要: |
| Objective: to observe the Glenn nye and acarbose clinical curative effect for the treatment of type 2 diabetes. Methods: our hospital endocrinology clinic treated with diet and exercise are not satisfied with 64 patients with type 2 diabetes, were randomly divided into experimental group (group that Glenn nai) (acarbose group) and control group, 32 cases of clinical treatment for 12 weeks. Results: two groups of patients with fasting blood glucose (FBG), postprandial 2 hours blood glucose (2 HPG) and glycosylated hemoglobin (HbA1c) were compared with before treatment significantly decreased (P < 0.05), but there was no statistically significant difference is compared between two groups (P > 0.05); Effects of weight, the effect of acarbose reduce weight is stronger than that Glenn nye, the difference statistically (P < 0.05); Gastrointestinal discomfort acarbose group was obviously higher than that of the Glenn nye group (is that Glenn nye group 10 times); The Glenn nye compared with acarbose, although the risk of hypoglycemia occurred in numerical increased, but there was no statistically significant difference. Conclusion: the Glenn nye and acarbose were significantly reduced fasting and postprandial blood glucose and HbA1c role; Compared with acarbose, that Glenn nye gastrointestinal discomfort caused fewer, better compliance, safety and tolerability. |
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