| 周策,唐太春,余乐来,龙浩然,黄德铨.自拟真人养脏汤治疗脾肾阳虚型溃疡性结肠炎的临床观察[J].实用中西医结合临床,2015,15(10): |
| 自拟真人养脏汤治疗脾肾阳虚型溃疡性结肠炎的临床观察 |
| Clinical Observation of Therapeutic Effect and Adverse Event of Self-prescribed Zhen ren yang zang Decoction(ZD) for Treatment of Spleen and Kidney Yang Deficiency type Ulcerative Colitis(UC) |
| 投稿时间：2015-06-03 修订日期：2015-06-23 |
| DOI： |
| 中文关键词: 溃疡性结肠炎/中药疗法 脾肾阳虚 真人养脏汤/治疗应用 |
| 英文关键词: Ulcerative Colitis(UC)/ TCD therapy Spleen and kidney yang deficiency Zhen ren yang zang Decoction(ZD)/Therapeutic use |
| 基金项目: |
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| 中文摘要: |
| 【目的】观察自拟真人养脏汤治疗脾肾阳虚型溃疡性结肠炎的临床效果及不良反应,并与美沙拉嗪进行疗效比较。【方法】将确诊的87例脾肾阳虚型溃疡性结肠炎患者采用完全随机分为2组,治疗组43例,对照组44例,治疗组以自拟真人养脏汤加减治疗,对照组用美沙拉嗪治疗,疗程均为6周,比较2组患者的临床疗效及复发率。【结果】治疗后2组患者在腹泻、黏液脓血便、腹痛、形寒肢冷、里急后重等症状以及综合疗效方面,治疗组均优于对照组,差异有统计学意义(P<0.01或P<0.05)。3个月内的复发率治疗组(27.03%)与对照组(35.48%)的差异无统计学意义。【结论】自拟真人养脏汤在治疗脾肾阳虚型溃疡性结肠炎方面疗效确切且安全,与美沙拉嗪治疗比较,在改善患者腹泻、黏液脓血便、腹痛、形寒肢冷、里急后重等症状更有优势,在防止复发方面差异不明显。 |
| 英文摘要: |
| Abstract:
Objective: to observe the therapeutic effect and adverse event of self-prescribed Zhen ren yang zang Decoction for treatment of spleen and kidney yang deficiency type UC, with comparison of Masalasine.
Methods: eighty-seven patients diagnosed with UC were randomly divided into two groups, 43 in treatment group and 44 in control group. Patients in treatment group was treated by modified ZD while those who in control group were given Masalazine. Treatment in both groups lasted for 6 weeks, and clinical effect and recurrence rate were evaluated afterwards.
Results: after treatment, the comprehensive effect, including alleviation of symptoms like diarrhea, bloody purulent stool with mucus, abdominal pain, cold sensation of body and extremities, and tenesmus, was superior to that of control group, with statistical significance(P<0.01 or P<0.05). There was no statistical significance between treatment group(27.03%) and control group(35.48%) regarding to recurrence rate within 3 months.
Conclusion:Self-prescribed ZD is effective and safe for the treatment of spleen and kidney yang deficiency type UC, and has more advantages in alleviation of symptoms like diarrhea, bloody purulent stool with mucus, abdominal pain, cold sensation of body and extremities, and tenesmus yet there is no significant difference in recurrence prevention when compared with Masalasine. |
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