| 邱慧萍.MMC与DDP交替腔内化疗治疗肺癌并心包积液[J].实用中西医结合临床,2015,15(5):13-14 |
| MMC与DDP交替腔内化疗治疗肺癌并心包积液 |
| Alternative Intra-pericardial Chemotherapy of MMC and DDP in the Treatment of Patients with Lung Cancer and Pericardial Effusion |
| |
| DOI： |
| 中文关键词: 肺癌并心包积液 腔内化疗 MMC（丝裂霉素） DDP（顺铂） |
| 英文关键词: Lung cancer, Pericardial effusion Intra-pericardial chemotherapy MMC (Mitomycin) DDP (Cisplatin) |
| 基金项目: |
|
| 摘要点击次数: 827 |
| 全文下载次数: 333 |
| 中文摘要: |
| 目的：观察总结丝裂霉素（MMC）与顺铂（DDP）交替化疗治疗肺癌并心包积液的疗效及毒性反应。方法：37例肺癌并心包积液患者均在B超或彩超引导下心包腔置入中心静脉导管引流，每日少量引流并MMC与DDP交替腔内化疗（其中MMC 2 mg/d、DDP 20~30 mg/d至MMC总量8~10 mg、DDP 90~100 mg）。结果：CR 25例，PR 10例，NR 2例，总有效率94.6%。治疗后发热4例，其中高热1例；胃肠道反应12例，主要为Ⅰ~Ⅱ度；骨髓抑制14例，主要为Ⅰ度。结论：心包腔闭式引流加MMC与DDP小剂量交替化疗是控制肺癌并心包积液的有效方法。 |
| 英文摘要: |
| Objective: To observe and summarize the efficacy and side effect of intra-pericardial chemotherapy of MMC and DDP on malignant pericardial effusion of lung cancer. Methods: Thirty-seven cases of lung cancer with malignant pericardial effusion were all drained with using central venous catheter guided by B-mode or color Doppler ultrasound. A small amount of drainage was conducted on daily basis with alternative intra-pericardial chemotherapy of MMC and DDP (there into, MMC 2 mg/d, DDP 20~30 mg/d to the total of MMC to 8~10 mg, DDP 90~100 mg). Result: The total effective rate was 94.6% with 25 cases of CR and 10 cases of PR. After treatment, 4 patients developed fever (1 case of high fever), 19 cases developed gastrointestinal tract reaction (mainly grade Ⅰ~Ⅱ), 14 developed myelosuppression (mainly grade Ⅰ). Conclusion: Central venous catheter drainage with alternative injection of MMC and DDP in small doses into pericardial cavity may be a better way to control malignant pericardial effusion of lung cancer. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
