| 张淑芳.利凡诺配伍顿服米非司酮用于中孕引产的临床观察[J].实用中西医结合临床,2015,15(2):8-9 |
| 利凡诺配伍顿服米非司酮用于中孕引产的临床观察 |
| Clinical Study of Rivanol Combined with a Draught of Mifepristone for Labor Induction of Midtrimester of Pregnancy |
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| DOI： |
| 中文关键词: 中孕引产 利凡诺 米非司酮 临床观察 |
| 英文关键词: Labor induction Rivanol Mifepristone Clinical study |
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| 摘要点击次数: 719 |
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| 中文摘要: |
| 目的：探讨利凡诺与米非司酮配伍用于临床中孕引产的疗效。方法：选择来我院因计划外怀孕、无引产禁忌证的中期妊娠孕妇80例，随机分为两组各40例。观察组：空腹或饭后2 h口服米非司酮150 mg，2 h后给予利凡诺100 mg羊膜腔内注射。对照组：直接给予利凡诺100 mg羊膜腔内注射。对两组引产效果及引产时间、产后2 h出血量、副作用等进行对比。结果：两组中均无第二次注药情况，两组引产成功率均为100.0%。产后2 h出血量：观察组为（85.46±13.55） ml，对照组为（149.52±22.63） ml，两组比较有显著性差异（P＜0.05）。胎盘胎膜残留率：观察组为37.5%、对照组为72.5%（P＜0.05）；清宫率：观察组为42.5%、对照组为80.0%（P＜0.05）；引产时间：观察组为（36.2±10.1） h，对照组为（49.9±17.8） h（P＜0.05）。结论：米非司酮是一种安全有效的促宫颈成熟及引产药物，与利凡诺配伍应用于中期妊娠引产，可以缩短产程，提高引产的有效率，减少胎盘胎膜残留，降低引产后出血和感染等并发症的发生。利凡诺配伍米非司酮应用于中孕引产简便、有效、安全、痛苦小，是较为理想的引产方法，值得临床推广应用。 |
| 英文摘要: |
| Objective: To study the clinical effect of the combination of the rivanol and mifepristone for the termination of midtrimester of pregnancy. Methods: 80 Pregnant patients with no induction of contraindications whose pregnancy were unscheduled and were in the midtrimester of pregnancy, were randomly divided into two groups (n=40 for each group). Patients in the observation group took 150 mg of mifepristone in fasting condition or 2-hour post meal, then after 2 hours intra-amniotic injection of 100 mg of rivanol were given. The patients in the control group were directly given intra-amniotic injection of 100 mg of rivanol. The labor induction, the time of induced abortion, the bleeding within 2 hours, and side effects were compared between two groups. Results: No second injection of medicine happened in both groups. The success rates of labor induction in both groups were 100.0%. However, there was a significant difference between two groups for the bleeding within 2 hours, (85.46±13.55) ml for the observation group, and (149.52±22.63) ml for the control group (P<0.05). The kiyomiya rate in the observation group was significantly different compared to that of the control group (42.5% vs 80.0%, P<0.05). The above observation proved that the residual rate of placenta and curettage rate in the observation group was significantly lower than that in the control group. Finally, the time of labor induction in the observation group was (36.2±10.1) h, while that in the control group was (49.9±17.8) h (P＜0.05). Conclusion: As a safe and effective drug for cervical ripening and labor induction, mifepristone combined with rivanol can shorten birth process, improve labor efficiency, reduce retained placenta, and decrease hemorrhage after induction and complications such as infection in the midtrimester of pregnancy. Such a method is simple, effective, safe, less painful for the induction of the midtrimester of pregnancy, and worth promoting in clinical practice. |
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