| 张娆.脂蛋白（a）与脑梗死急性期中医证型及危险因素的研究[J].实用中西医结合临床,2015,15(1):4-7 |
| 脂蛋白（a）与脑梗死急性期中医证型及危险因素的研究 |
| The Study on the Relationship Among Lipoprotein(a), the Traditional Chinses Medicine Syndrome Types and Risk Factors of AcuteCerebral Infarchtion |
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| DOI： |
| 中文关键词: 脑梗死急性期 危险因素 脂蛋白（a） 中医证候 |
| 英文关键词: Actue stage of cerebral infraction Risk factors Lp(a) Syndrome types of TCM |
| 基金项目: |
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| 摘要点击次数: 790 |
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| 中文摘要: |
| 目的：通过脑梗死急性期不同的中医证型脂蛋白（a）变化的临床观察以探讨脂蛋白（a）与脑梗死急性期不同中医证型的相关性。方法：选取符合标准的脑梗死急性期住院患者331例为脑梗死急性期组，选取门诊体检科正常健康者100例为对照组。两组分别记录年龄、性别、体重指数及脂蛋白（a）水平。脑梗死急性期组记录是否患有冠心病、高血压、糖尿病。对脑梗死急性期组按照中医辨证分型分为8型，即：风痰瘀血、闭阻脉络证，肝阳暴亢、风火上扰证，痰热腑实、风痰上扰证，气虚血瘀证，阴虚风动证，痰热内闭清窍证，痰湿蒙塞心神证，元气败脱、神明散乱证。通过统计学方法分析两组在年龄、性别、肥胖、脂蛋白（a）上是否存在差异；脑梗死急性期组的脂蛋白（a）与相关危险因素的关系；脑梗死急性期组的脂蛋白（a）与不同中医证型的对比。结果：脑梗死急性期组和对照组年龄、性别、肥胖比较统计学上无差异，两组脂蛋白（a）水平统计学有显著差异（P＜0.01）。将脑梗死急性期组患者根据脂蛋白（a）水平分为脂蛋白（a）正常组和脂蛋白（a）升高组两组，两组危险因素比较，高血压、糖尿病统计学无差异（P＞0.05），而冠心病、肥胖有差异（P＜0.05）。经统计分析，脑梗死急性期组不同中医证型的脂蛋白（a）有差异（P＜0.05）。结论：脂蛋白（a）水平与脑梗死急性期密切相关，脂蛋白（a）异常升高与冠心病、肥胖在统计学上有相关性。脑梗死急性期组中医证型中脂蛋白（a）主要与风痰瘀血、闭阻脉络证关系密切。 |
| 英文摘要: |
| Objective: To investigate the relationship among lipoprotein(a) and the different TCM syndrome types of acute cerebral infarchtion by analyzing the changes of lipoprotein(a) in different TCM syndrome types of cerebral infarchtion. Methods: 331 Patients of acute cerebral infarchtion who met the inclusion criterias in the hospital wards as the CI group, and 100 healthy subjects from physical examination department in outpatient as the control group. Two groups were respectively recorded age, sex, body mass index (BMI), Lp(a). The CI group were recorded whether patients suffering from coronary heart disease, hypertension and diabetes. According to the syndrome differentiation of TCM, the CI group were divided into eight types, the wind-phlegm, blood stasis and closing resistance of choroids syndrome, the liver Yang and wind-heat disturbance syndrome, the phlegm-heat, bomel stoppage and wind-phlegm disturbance syndrome, the Qi deficiency with blood stasis syndrome, the wind formation due to Yin deficiency syndrome, the phlegm-heat within the clear orifices syndrome, the phlegm-damp moncey spirit syndrome, the Yuan-Qi vitality exhaustion and unconsciousness syndrome. The differences in age, sex, BMI, Lp(a) between two groups were analyzed by statistical methods, the relationship between Lp(a) and risk factors were also analyzed, the Lp(a) level among different TCM syndrome types were compared. Results: There was no statistically significant difference in age, sex and BMI of the CI group and the control group. The Lp(a) level was statistically different (P＜0.01) between two groups. In the CI group, there was no significant difference in the risk factors of hypertension and diabetes btween the normal Lp(a) patients and higher Lp(a) patients (P>0.05), but there was significant difference in coronary heart disease and obesity (P<0.05). The Lp(a) levels in the different TCM syndrome types were statistically significant (P<0.05). Conclusion: Lp(a) is closely related to acute cerebral infraction. The abnormal elevation of Lp(a) is related to coronary heart disease and obesity. In the different TCM syndrome types of acute cerebral infraction, Lp(a) is closly related to the wind-phlegm, blood stasis and closing resistance syndrome. |
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