| 毛艳玲 何芳.西格列汀治疗合并糖调节受损的肥胖患者的疗效分析[J].实用中西医结合临床,2014,14(11):7-8 |
| 西格列汀治疗合并糖调节受损的肥胖患者的疗效分析 |
| Analysis of Therapeutic Effect of Sitagliptin Therapy Combined with Impaired Glucose Regulation in Patients with Obesity |
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| DOI： |
| 中文关键词: 糖调节受损 胰岛素抵抗 西格列汀 |
| 英文关键词: IGR IR Sitagliptin |
| 基金项目: |
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| 中文摘要: |
| 目的：观察西格列汀对肥胖合并糖调节受损患者的胰岛功能、血糖、体重指数、腰围等指标影响，探讨西格列汀在糖尿病预防及早期治疗方面的作用。方法：选取2011年6月~2013年11月首次门诊就诊于泉州市第一医院内分泌科的70例糖调节受损（IGR）患者，年龄（48.61±5.07）岁，未经过任何调脂、降糖及其他治疗。随机分为两组，即A组（35例）：进行糖尿病、低脂饮食，运动锻炼；B组（35例）：同样进行饮食控制、体育锻炼（同A组），同时加用西格列汀100 mg，qd；6个月后，观察空腹血糖（FBG）、餐后2 h血糖（2 hPG）、空腹血清胰岛素、餐后2 h血清胰岛素、胰岛素抵抗指数（HOMA-IR）、腰围、体重指数（BMI）等指标的变化。结果：A组入组后6个月，空腹及餐后2 h血清胰岛素水平、HOMA-IR无明显变化，差异无统计学意义；空腹及餐后2 h血糖、BMI、腰围水平显著降低，差异有统计学意义（P＜0.05）。B组治疗后，空腹及餐后2 h血糖、空腹及餐后2 h血清胰岛素水平、HOMA-IR、BMI、腰围水平均显著降低，差异有统计学意义（P＜0.01）。结论：西格列汀具有明显的降低高胰岛素血症及改善胰岛素抵抗的作用。 |
| 英文摘要: |
| Objective: To observe the effects of Sitagliptin on pancreatic islet function, blood glucose, body mass index, waist circumference and other indicators of impaired glucose regulation in patients with obesity; and to explore the role of Sitagliptin in the diabetes prevention and early treatment. Methods: Chose 70 cases of IGR patients who visited endocrinology department of the first affiliated hospital in Quanzhou city since June 2011 to November 2013, without any lipid-lowering, hypoglycemic and other treatment. They were divided into 2 groups randomly: group A (35 cases), were given diabetes treatment, lower lipid diet, exercise and training; group B (35 cases), were given diet control, exercise and training (same as group A), at the same time, were added Sitagliptin 100 mg, qd. After 6 months, observed the change of FBG, 2 hPG, serum insulin in empty stomach, measuring of serum insulin 2 hours after dinner, HOMA-IR, waist circumference, BMI and other index. Results: After 6 months of treatment, group A had no significant change in serum insulin in empty stomach and 2 hours after dinner and HOMA-IR. FBG, 2 hPG, there were no significant difference; BMI and waist circumference decreases evidently, differences were significant (P＜0.05). Group B had significant change in FBG, 2 hPG, serum insulin level in empty and 2 hours after dinner, HOMA-IR, BMI and waist circumference decreased evidently, there were significant difference (P＜0.01). Conclusion: Sitagliptin can reduce hyperinsulinemia and improve insulin resistance obviously. |
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