| 胥保华.黄芪注射液对非小细胞肺癌患者辅助化疗后免疫状态的改善作用[J].实用中西医结合临床,2014,14(9):3-5 |
| 黄芪注射液对非小细胞肺癌患者辅助化疗后免疫状态的改善作用 |
| The Improvement Effects of Astragalus Injection on Immune Status after Adjuvant Chemotherapy in Lung Cancer Patients |
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| DOI： |
| 中文关键词: 非小细胞肺癌 黄芪注射液 辅助化疗 免疫状态 |
| 英文关键词: Non-small cell lung cancer Astragalus injection Adjuvant chemotherapy Immune status |
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| 中文摘要: |
| 目的：探讨黄芪注射液对肺癌术后辅助化疗患者免疫状态的影响。方法：选取我院2010年9月~2013年9月接受肺癌根治术的ⅢA期非小细胞肺癌患者200例，随机分为实验组和对照组各100例，观察并记录两组患者辅助化疗后的免疫状态。免疫状态通过测定T细胞亚群、NK细胞及免疫球蛋白水平进行评估。结果：辅助化疗结束时两组肺癌患者的CD3+T细胞、CD4+T细胞和CD4+/CD8+比值均明显下降，而CD8+T细胞明显增加，NK细胞活性明显弱于正常人，说明肺癌患者辅助化疗后的细胞免疫处于较低水平。在辅助化疗后1周，患者CD3+T细胞、CD4+T细胞以及CD4+/CD8+比值进一步下降；实验组患者辅助化疗后1个月，CD3+T细胞、CD4+T细胞及NK细胞活性首先恢复正常；对照组患者以上三种细胞比例虽然有所上升，但速度较为缓慢，直到化疗结束后3个月时仅CD4+T细胞达到正常水平。在化疗后第1周至第3个月的各观察时间内，实验组CD8+T细胞和CD4+T细胞百分比均显著高于对照组。两组患者的体液免疫状态变化趋势与细胞免疫类似。结论：黄芪注射液可显著提高肺癌术后辅助化疗患者的免疫功能。 |
| 英文摘要: |
| Objective: To evaluate the effects of astragalus injection on immune status in non-small cell lung cancer patients undergoing adjuvant chemotherapy. Methods: A randomized clinical trial was carried out at our hospital from September 2010 to September 2013. 200 Patients with non-small cell lung cancer were randomly assigned to experimental group and control group. Patients were evaluated during treatment period. Results: The levels of CD3+T cell, CD4+T cell and CD4+/CD8+T cell in both group significantly decreased before adjuvant chemotherapy, while the level of CD8+T cell significantly increased, the activity of NK cell were much weaker than normal subjects. In the first month after adjuvant chemotherapy, the patients’ CD3+T cell, CD4+T cell and CD4+/CD8+T cell decreased further. 1 month after adjuvant chemotherapy, the level of CD3+T cell, CD4+T cell and NK cell in the experimental group returned to normal much earlier than that of the control group. We got similar results in humoral immunity status. Conclusion: Astragalus injection could increase immune status in non-small cell lung cancer patients undergoing adjuvant chemotherapy. |
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