| 熊英.静脉与口服铁剂治疗肾性贫血疗效的临床观察[J].实用中西医结合临床,2013,(1):5-6 |
| 静脉与口服铁剂治疗肾性贫血疗效的临床观察 |
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| DOI： |
| 中文关键词: 肾性贫血 蔗糖铁 富马酸亚铁 促红细胞生成素 |
| 英文关键词: Renal anemia Iron sucrose Injection Ferrous fumarate capsules Erythropoietin |
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| 中文摘要: |
| 目的：观察慢性肾功能不全患者静脉和口服补铁治疗肾性贫血的疗效、不良反应的发生情况以及对促红细胞生成素（EPO）使用效应的比较。方法：将62例肾性贫血患者随机分为静脉组和口服组，每组31例，观察期10周。所有患者均常规使用EPO治疗，剂量为100 U/（kg·周），皮下注射，若患者血红蛋白（Hb）达100 g/L，则将EPO剂量减少50%；若患者Hb达120 g/L则将EPO剂量减少75%。口服组给予富马酸铁口服，静脉组给予蔗糖铁注射液静脉滴注。观察用药前、用药后4周、用药后8周、用药后10周的血红蛋白（Hb）、红细胞压积（Hct）、铁蛋白（SF）、不良反应以及EPO使用量。结果： 治疗后两组患者的Hb、Hct、SF均较治疗前有明显升高，而静脉组升高幅度显著高于口服组（P <0.05），两组患者EPO使用量在治疗后较治疗前均有所减少，而静脉组减少明显（P <0.05），静脉组不良反应的发生率明显低于口服组，EPO的效应明显高于口服组。结论：静脉补铁能及时有效地补充肾性贫血患者所需的铁剂，使贫血状况改善，不良反应少，可安全应用，并能增强EPO效应，减少其用量。 |
| 英文摘要: |
| Objective:To compare the therapeutic effects and adverse reactions between intravenous and oral iron, and the effects of erythropoietin （EPO） in patients with chronic renal failure.Methods:62 Patients with renal anemia were randomly divided into 2 groups:intravenous group and oral group,31 in each.The duration of administration lasted for 10 weeks.All patients received regular EPO,with the dose of 100 U/(kg·week),if the patient's hemoglobin(Hb) was more than 100 g/L,then the dose of EPO decreased 50% if the patient's Hb was more than 120 g/L,then the dose decreased 75%.The oral group was treated with ferrous fumarate capsules,po;the intravenous group was treated with iron sucrose injection,iv.The levels of Hb,hematocrit,serum ferritin,adverse reaction and dose of EPO before and 4 weeks,8 weeks,10 weeks after the administration were observed. Results:The levels of Hb,Hct and SF in both groups after administration increased compared with before administration; and there was significant difference between the intravenous group and the oral group(P <0.05).The dosages of EPO in both groups after administration were lower than before administration,whereas the dosage in the intravenous group decreased significantly(P <0.05).In the intravenous group,the adverse reactions were significantly lower and the effect of EPO was significantly higher than in the oral group.Conclusions:The intravenous iron can not only supply the iron to the patients with renal anemia,but also increase the effect of EPO and reduce the dosage of EPO.The adverse reactions of intravenous iron are low and it is safe and convenient. |
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