| 张艳晖 彭雪 刘雄飞 张艳丽 张经生 徐达津 洪婷 魏骏.中药内服外洗治疗迟发型痤疮伴高雄激素血症相关分析[J].实用中西医结合临床,2012,(6):1-4 |
| 中药内服外洗治疗迟发型痤疮伴高雄激素血症相关分析 |
|
| |
| DOI： |
| 中文关键词: 张氏枇杷清肺方 多囊卵巢综合征 迟发性痤疮 高雄性激素血症 |
| 英文关键词: Zhang loquat Qingfei decoction Polycystic ovarian syndrome Tardive acne Hyperandrogenemia |
| 基金项目:江西省卫生厅中医药科研基金资助项目（2009A115） |
|
| 摘要点击次数: 600 |
| 全文下载次数: 263 |
| 中文摘要: |
| 目的：观察中药内服外洗治疗多囊卵巢综合征（PCOS）患者中伴高雄激素血症及迟发性痤疮者临床疗效。方法：将入选患者采用中医辨证分型后随机分为治疗组和对照组，治疗组采用本院中药协定处方张氏枇杷清肺方内服外洗患处，连续治疗3个月；对照组采用达英-35，自然月经或孕激素撤退出血后第1天开始口服，每日1片，连服21 d后停药，撤退性出血后第1天开始服用下一周期，重复3个周期。观察患者治疗前、治疗后1个月、治疗后3个月、治疗停药后3个月、治疗停药后6个月的临床皮损情况、黄体生成素（LH）、卵泡刺激素（FSH）、睾酮（T）及卵巢变化、子宫大小和内膜厚度各项指标情况变化。结果：（1）在改善痤疮临床症状方面，治疗组在治疗后1个月效果明显优于对照组（P <0.05）；治疗后3个月两组无显著性差异（P >0.05）；在停药后复诊过程中，治疗组症状反复情况明显低于对照组（P 均<0.05），有统计学差异。（2）在患者激素水平对比方面，入选患者治疗前血清雄激素水平均明显升高，但在治疗后1个月治疗组能显著降低雄激素水平，起效时间快于对照组（P <0.05），治疗后3个月两组无差异（P >0.05），停药后治疗组血清雄激素水平升高慢于对照组，有统计学差异（P <0.05）。（3）超声检查双侧卵巢多囊、子宫大小及内膜改变情况方面，两组对比均无显著性差异（P >0.05）。结论：通过疗效观察，张氏枇杷清肺方与达英-35都具有改善痤疮皮损及降低雄性激素水平功效，但张氏枇杷清肺方症状缓解起效时间更快、复发率更低、激素水平反弹更少，且无不良反应，值得临床推广。 |
| 英文摘要: |
| Objective:To observe the clinical efficacy of the traditional chinese medicine therapy in treatment of internal and external medicine for polycystic ovary syndrome ( PCOS ) patients with hyperandrogenemia and tardive acne.Methods:Patients were divided into the treatment group and the control group after syndrome differentiation of traditional chinese medicine,the treatment group used the medicine prescription of our hospital’s Zhang loquat Qingfei decoction for oral use and washing the affected area,for 3 months;the control group used the ethinylestradiol and cyproterone acetate tablets,after natural menstrual or progestogen,1 tablet a day,stop medicine after 21 days,3 cycles repeat.Before treatment,1 month after treatment,3 months after treatment,3 months after stopping treatment and 6 months after stopping treatment,discontinuation of clinical lesions, luteinizing hormone (LH),follicle stimulating hormone (FSH),testosterone (T)and changing trend were observed.Results:(1)In the improvement of acne clinical symptoms,the treatment group effect was better than the control group after one month's treatment(P <0.05);There was no significant difference between two groups after 3 months's treatment(P >0.05);the treatment group was lower recurrent than the control group after stopping medicine(P <0.05),there was a statisticst difference.(2)Contrast with hormone levels,the treatment group's androgen was reduced more effective than the control group after one month's treatment(P <0.05),and there was no significant difference between two groups after 3 months's treatment(P > 0.05),the treatment group's rising level of androgen was lower than the control group after stopping medicine, there was no significant difference between two groups after 3 months’s treatment（P <0.05).(3)Ultrasound exam the situation of bilateral polycystic ovaries,uterine size and endometrial changes,two groups had no significant difference(P >0.05).Conclusion:Through the clinical observation,Zhang loquat Qingfei decoction and cyproterone acetate tablets have improve acne and reducing the level of androgen effects.Zhang Loquat Qingfei decoction onset time of the former is faster, lower recurrence rate,lower rebounce of the hormone levels, and no side effects and so on,it’s worthy to the clinical promoted. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
