| 黄宇玫 罗文艳.竹叶黄酮对小鼠H22肿瘤抑制作用的研究[J].实用中西医结合临床,2012,(5):1-3 |
| 竹叶黄酮对小鼠H22肿瘤抑制作用的研究 |
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| DOI： |
| 中文关键词: H22 竹叶黄酮 生命延长率 抑瘤率 脏器指数 |
| 英文关键词: H22 Bamboo flavonoids Life extension rate Tumor inhibition rate Organ index |
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| 中文摘要: |
| 目的：探讨竹叶黄酮对荷瘤小鼠的抑瘤作用。方法：观察不同剂量竹叶黄酮对荷瘤小鼠肿瘤的抑瘤率、生命延长率、胸腺指数、脾脏指数以及用药前后体重变化等指标的影响。结果：竹叶黄酮具有一定的体内抗肿瘤作用，大、小剂量组的抑瘤率分别为31.6%、9.4%。竹叶黄酮组对荷瘤小鼠虽然没有环磷酰胺那么明显的抗肿瘤作用，但其毒副作用较少，还能延长腹水瘤小鼠的生存时间，增强小鼠免疫能力。结论：竹叶黄酮对小鼠恶性腹腔积液的形成具有抑制作用，还能抑制实体瘤的生长并增强小鼠机体的免疫能力，这为临床应用提供了实验依据。 |
| 英文摘要: |
| Objective:To investigate tumor inhibitory effect of bamboo flavonoids． Methods : Hepatic cancer H22 model in mice was performed,observed the tumor inhibitory rate and life extension rate,index of thymus and spleen ,weight with different dosage of bamboo flavones .Results:Bamboo flavonoids had some anti-tumor effect in vivo, The tumor inhibition rate of the big and small dose group was 31.6%、9.4% respectively.Compared with CTX, bamboo flavonoids have less obvious anti-tumor effect ,but fewer side effects , also can extend survival time of tumor-bearing mice in ascites, enhance immunity in mice.Conclusion:Bamboo flavonoids on murine malignant peritoneal effusion formation is inhibited, and enhancement of murine immune capacity, which can provide the experimental basis for clinical application. |
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