| 李晓君 柳丽萍 程淑华.非洛地平合普伐他汀治疗高血压颈动脉硬化斑块的临床研究[J].实用中西医结合临床,2012,(4):1-2,7 |
| 非洛地平合普伐他汀治疗高血压颈动脉硬化斑块的临床研究 |
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| 中文关键词: 高血压 颈动脉内膜-中层厚度 颈动脉斑块 非洛地平 普伐他汀 |
| 英文关键词: Hypertension Carotid artery intima-media thickness Carotid atherosclerotic plaque Felodipine Prastastin |
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| 中文摘要: |
| 目的：探讨非洛地平联合普伐他汀治疗高血压合并颈动脉斑块的疗效。方法：90例高血压合并颈动脉斑块患者随机分为两组：A组：非洛地平+普伐他汀45例；B组：贝那普利+普伐他汀45例，疗程12个月，控制血压及强化降脂。血压不达标加用氢氯噻嗪25 mg，血浆低密度脂蛋白降至2.1 mmol/L后，普伐他汀改为20 mg。应用彩色多普勒超声检测患者治疗前后颈动脉内膜-中层厚度（CIMT）、粥样硬化斑块以及血脂、血压水平。结果：两组患者治疗后SBP、DBP及血TC、TG、LDL-C较治疗前显著降低（P 均<0.05），但治疗后两组间比较差异无显著性（P >0.05）；与治疗前相比，两组均能改善患者CIMT及颈动脉斑块（P 均< 0.05），A组患者改善效果更加明显（P <0.05）。结论：非洛地平联合普伐他汀对治疗高血压颈动脉斑块有确切疗效，值得临床应用。 |
| 英文摘要: |
| Objective:To observe the effect of felodipine and prastastin combined on carotid artery intima-media thickness(CIMT)and carotid atherosclerotic plaques in patients with hypertension.Methods:Ninety hypertension patients with different extent of the CIMTs and plaques examined by cervical artery ultrasonic were divided into two groups.Group A of 45 patients received felodipine and prastastin ,Group B of 45 patients received benazepril and prastastin.Hydrochlorthiazide 25 mg was added if blood presures not controlled properly,and prastastin 20 mg was given when LDL-C below 2.1 mmol/L.Serum lipids were detected every three months and all the patients received the cervical artery ultrasonic to study the changes of CIMT and the grade of the plaques twelve months later.Results:SBP and DBP were significantly decrease after 6 weeks treatment,but there was no significant difference between the two groups.So do TC,TG,LDL-C,HDL-C.But CIMT were decreased more significantly in group A after treatment than in group B(P <0.05).Conclusion:Therapy of felodipine and prastastin intensive lipid-lowering combined can decrease CIMTs and reduce carotid atherosclerotic plaques significantly. |
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