| 刘小莲 谢晶日 李明.益气养阴活血法对胃癌前病变大鼠MEK/ERK的影响[J].实用中西医结合临床,2010,(6):3-4，28 |
| 益气养阴活血法对胃癌前病变大鼠MEK/ERK的影响 |
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| DOI： |
| 中文关键词: 益气养阴活血法 胃癌前病变 MEK ERK |
| 英文关键词: Yiqi Yangyin Huoxue principle Precancerous lesions of gastric carcinoma MEK ERK |
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| 中文摘要: |
| 目的：研究益气养阴活血法对胃癌前病变大鼠MEK／ERK的影响。方法：75只Wistar大鼠被随机分成模型组、空白组、中药低剂量组、中药高剂量组和维霉素组，每组15只。采用以MNNG为主的四因素联合造模法建立胃癌前病变的大鼠模型，维霉素组给予维霉素混悬液1.0g/kg每日1次灌胃；中药低剂量组、中药高剂量组大鼠分别给予生药浓度为1.0g/mL、2.0g/mL的益气养阴活血方中药煎剂（10mL/kg）每日1次灌胃。16周后观察大鼠胃黏膜病理变化，以及对MEK1和ERK1水平的影响。结果：模型组大鼠胃黏膜MEK1、ERK1水平与空白组比较升高（P <0.05），中药高剂量组大鼠胃黏膜MEK1、ERK1水平与模型组比较降低（P <0.05），中药高剂量组大鼠胃黏膜病理改变得到改善。结论：益气养阴活血法可改善胃癌前病变大鼠胃黏膜病理状况，下调胃黏膜MEK1及ERK1水平。 |
| 英文摘要: |
| Objective:To study the effect of Yiqi Yangyin Huoxue principle on the MEK/ERK pathway in rats with precancerous lesions of gastric carcinoma. Method: 75 Wistar rats were randomly divided into model group, normal control group, low dose group, high dose group and weimeisu group.The rat model of precancerous lesions of gastric carcinoma（PLGC） was established by four pathogenic factors in which MNNG was mainly used. Weimeisu was given 1.0g/kg per day in weimeisu group；Yiqi Yangyin Huoxue recipe of 1.0g/ mL,2.0g/mL drug concentration were given 10mL/kg per day in low dose group and high dose group. After 16 weeks，to observe the pathological changes in rat gastric mucosa as well as MEK1 and ERK1 levels. Result: The level of MEK1 and ERK1 in model group was significantly increased compared with normal control group(P <0.05).The level of MEK1 and ERK1 in high dose group was significantly reduced compared with the model group(P <0.05).The pathological changes were significantly improved in high dose group.Conclusion:Yiqi Yangyin Huoxue principle can improve the pathological conditions of gastric mucosa in rat with PLGC,and it can also prevent the progress of PLGC by reducing MEK1 and ERK1 levels. |
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