| 叶菁 邱丽瑛.金匮肾气丸对“恐伤肾”模型小鼠醛固酮水平的调节作用[J].实用中西医结合临床,2010,(6):1-3 |
| 金匮肾气丸对“恐伤肾”模型小鼠醛固酮水平的调节作用 |
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| DOI： |
| 中文关键词: 金匮肾气丸 恐伤肾 心理应激 小鼠 醛固酮 |
| 英文关键词: Jin Kui Shen Qi Wan Terror leading to disorder of kidney Psychological stress Mice Aldosterone |
| 基金项目: |
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| 中文摘要: |
| 目的：通过建立“恐伤肾”小鼠模型，观察其醛固酮水平的变化，探讨心理应激对醛固酮水平的影响及其机制，为进一步研究应激条件下动物免疫功能的变化提供实验依据。方法：采用自制小站台水环境实验，剥夺小鼠睡眠，使其活动受限，造成“恐惧”心理应激，建立“恐伤肾”模型。结果：应激24h组小鼠血清、组织中醛固酮水平的改变与正常对照组相比较，有极显著性差异（P <0.01）；给予金匮肾气丸后，小鼠血清、组织中醛固酮水平均低于相应应激组，有显著性差异（P <0.05）。结论：心理应激可以引起小鼠醛固酮水平的改变，影响机体免疫功能，导致体质衰弱、病感或疾病；金匮肾气丸可以改善应激条件下小鼠醛固酮水平的变化，对心理应激小鼠的免疫功能有较好的调节作用。 |
| 英文摘要: |
| Objective:To observe the change about the level of aldosterone and to research the effect which can provides experimental basis for the role of immunological function under psychological stress via establishing“terror leading to disorder of kidney”mice model. Method: Use platform-over-water environment, deprive sleep of the mouse, restrict their activities in order to cause “terror” psychological stress and to establish the “terror leading to disorder of kidney” mouse model. Results: Compared with the normal control group, the serum and hormone level of the 24 hours stress group mice has extreme difference(P <0.01).After being prescribed by Jin Kui Shen Qi Wan, the serum and hormone level of the mice was better than the corresponding group(P <0.05).Conclusion: Psychological stress changes the level of aldosterone and immune function of the mouse, which lead to illness or disease；Jin Kui Shen Qi Wan can improve the level, it also has better regulation of immunological function to the mouse which is under the psychological stress. |
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