| 吴静 赵春 徐丹华 陆为民 周晓白 单兆伟 B.M.E.von Blomberg A. S. Pena.腹泻型肠易激综合征脾虚患者乳糜泻血清标志物初步筛查[J].实用中西医结合临床,2010,(5):3-5 |
| 腹泻型肠易激综合征脾虚患者乳糜泻血清标志物初步筛查 |
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| DOI： |
| 中文关键词: 乳糜泻 腹泻型肠易激综合征 脾虚证 抗麦胶抗体 抗组织转谷氨酰胺酶抗体 |
| 英文关键词: Ventilator-Associated Pheumonia Chinese traditional and Western medicine T cell subsets NK cell |
| 基金项目:国家中医药管理局中医药留学回国人员科技活动择优资助课题（国中医药科2003LHR10号） |
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| 中文摘要: |
| 目的：初步筛查腹泻型肠易激综合征脾虚患者乳糜泻血清标志物，调查其发病状况。方法：自2002年12月~2008年8月搜集73例腹泻型肠易激综合征脾虚证患者血清，其中女性28例，男性45例，平均年龄（50±15）岁，均为江苏汉族人，进食米面食品。分别测定乳糜泻血清标志物抗麦胶抗体（IgG-AGAs）、抗组织转谷氨酰胺酶抗体（IgA-tTGs）以及血清免疫球蛋白水平（IgG、IgA、IgM）。结果：73例病患中有6例乳糜泻抗体阳性（8.2%），其中5例IgG-AGAs阳性（6.8%），2例IgA-tTGs阳性（2.7%），两种抗体均为阳性者1例，6例患者均无IgA缺乏。随访发现6例血清标志物阳性患者均婉拒十二指肠活检进一步确诊检查，而选择去麦胶饮食（GFD）治疗。病例3和病例4于1年后腹泻停止，病例3开始生长发育，而病例4体重不再减轻。结论：腹泻型肠易激综合征脾虚证患者乳糜泻血清标志物筛查结果显示，江苏地区可能存在乳糜泻患者，对麦胶敏感可能是我国慢性腹泻患者的病因之一。 |
| 英文摘要: |
| Objective:Primary Screen the serum markers of coeliac disease in spleen deficieycy IBS-D patients,to investigation its populations.Methods:Serum of 73 cases were collected from December 2002 to August 2008. These patients were Chinese Han from Jiangsu province with wheat product in their diets. They had diarrhoea predominant irritable bowel syndrome (IBS-D) fulfilled ROME II criteria and in addition had spleen deficiency, 28 women and 45 men, mean age(50±15)years old.serological tests for CD serum markers,IgG anti-gliadin antibodies (AGAs), IgA anti-tissue transglutaminase antibodies (tTGs) and total immunoglobulin test were arranged to screen for CD in these patients.Results:The results showed that 6 out of 73 patients(8.2%) were positive for CD antibodies,5 (6.8%) were positive for IgG-AGAs and 2(2.7%)were positive for IgA-tTGs. Total IgA measurement did exclude IgA deficiency. Follow-up has demonstrated that these serological positive patients did not want to have invasive diagnosis by duodenal biopsy but preferred to have gluten free diet (GFD) directly. In two persons (cases 3 and Case 4) who accepted GFD for one year, diarrhoea stopped.Case 3 started to thrive and case 4 stopped losing weight.Conclusion:Our serological screening demonstrated that CD might exist in Jiangsu province. Sensitive to gluten could be one of pathogenic factor for chronic diarrhea in China. |
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