| 李爱青 焦榕芳 刘洁 曾怡.补肾健脾法治疗原因不明复发性流产临床研究[J].实用中西医结合临床,2010,(3):8-9 |
| 补肾健脾法治疗原因不明复发性流产临床研究 |
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| DOI： |
| 中文关键词: 流产 CD4+CD25+调节性T细胞 补肾健脾 |
| 英文关键词: Abortion CD4+CD25+ regulatory T cells nourishing kidney and strengthing spleen |
| 基金项目:江西省卫生厅中医药科研基金（编号：2008L0046） |
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| 中文摘要: |
| 目的：探讨补肾健脾法对原因不明复发性流产(URSA)外周血CD4+CD25+调节性T细胞(Tr)的影响。方法：南昌大学第四附属医院2008年1月~2009年12月就诊的20例URSA患者，采用双荧光标记流式细胞分析技术，检测补肾健脾治疗前后外周血CD4+CD25+Tr细胞表达频率的变化。结果：补肾健脾中药治疗后，URSA患者外周血中CD4+CD25+Tr较治疗前明显增加（P <0.05），中药安胎妊娠成功妇女CD4+CD25+Tr显著高于妊娠失败者。结论：补肾健脾可提高外周血CD4+CD25+Tr数量，能够提高机体保护性免疫功能，维持机体内环境稳定，为URSA的有效治疗方法。 |
| 英文摘要: |
| Objective:To investigate the influence of nourishing kidney and strengthing spleen on peripheral blood CD4+CD25+Tr regulatory cells of unexplained recurrent spontaneous abortion (URSA) patient.Methods:20 URSA patients were enrolled in our study from January,2008 to December,2009 in the fourth Affilinited Hospital of NanChang University .The percentage of D4+CD25+Tr in peripheral blood were measured by double-label flow cytometric analysis before and after treatment.Results:After nourishing kidney and strengthing spleen therapy ,the percentage of CD4+CD25+Tr increased significantly（P<0.05）.The percentage of CD4+CD25+Tr was significantly higher in successful pregnant women than those in pregnant loss after the Traditional Chinese Medicine therapy. Conclusions: Nourishing kidney and strengthing spleen therapy can enhance the percentage of CD4+CD25+Tr in peripheral blood,can increase protecting immune function,and maintain the organism inner environment,as to be an effective cure method. |
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