| 高璟 刘叶 兰琴 王倩 倪晨.清热祛湿法治疗流行性感冒60例临床疗效观察[J].实用中西医结合临床,2010,(3):1-2，4 |
| 清热祛湿法治疗流行性感冒60例临床疗效观察 |
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| DOI： |
| 中文关键词: 流行性感冒 清热祛湿法 蒿芩清胆汤加减 TNF-?琢 IL-6 |
| 英文关键词: Influenza the method of eliminating heat and wetness evil Haoqin Qingdan Tang TNF-?琢 IL-6 |
| 基金项目:广东省佛山市医疗卫生科研计划立项课题（项目号：2008327） |
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| 中文摘要: |
| 目的：观察、比较运用清热祛湿法（蒿芩清胆汤加减）治疗流感（湿阻少阳证）的临床疗效，评价清热祛湿药物的免疫调节作用。方法：将60例流行性感冒湿阻少阳证患者随机分为治疗组30例与对照组30例，治疗组予蒿芩清胆汤加减，每日1剂，水煎服2次，1周为1个疗程；对照组予利巴韦林，每次100mg，每日3次，连服5d，在症状出现2d内开始用药。观察两组用药后临床疗效、退热过程、症状改善及两组治疗前后血清TNF-?琢、IL-6水平。结果：（1）治疗组治愈26例(86.7%)，对照组治愈12例(40.0%)，两组治愈率有显著性差异(P <0.05)；治疗组退热时间、症状改善均明显优于对照组，差异有统计学意义 (P <0.05或P <0.01)。（2）两组治疗后血清TNF-?琢、IL-6水平均有所下降，治疗组较对照组下降明显，差异均有统计学意义（P <0.05）。结论： 清热祛湿法治疗流行性感冒（湿阻少阳证）临床疗效满意，可明显降低流感病毒感染患者血清中TNF-?琢及IL-6的含量。 |
| 英文摘要: |
| Objective:To observe and compare the clinical effect of influenza(wet resistance in shao-yang)by the method of eliminating heat and wetness evil (Haoqin Qingdan decoction),Evaluation the immunomodulatory effect of the drugs of eliminating heat and wetness evil.Methods:Sixty patients with influenza of the syndrome wet resistance in Shao-yang were randomly divided into two groups as treatment and control group ,each of them contained 30 cases and the treated group was given Haoqin Qingdan Decoction respectively for orally taking,bid,for one week as a treatment course.The control group was given ribavirin,100mg,tid,continuous taking 5 days. 2 days after the onset of symptoms began medication.Clinical efficacy were observed after treatment, cooling time,symptom improvement, and the TNF-?琢, IL-6 levels of serum were observed.Results:(1)Treatment group was cured 26 cases (86.7%), the control group 2 cases (40.0%), the two groups was significant difference in cure rate (P <0.05).The cooling time and the symptoms improve time of treatment group was shortter than the control group, the difference was statistically significant (P <0.05 or P <0.01).(2)The serum TNF-α, IL-6 levels of both group decreased after treatment, the treatment group compared with the control group, the differences were statistically significant (P <0.05).Conclusion:Heat treatment of influenza dampness (wet resistance in Shao-yang) clinical efficacy is very significantly reduced influenza virus infection in TNF-?琢 and serum IL-6 levels. |
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