| 夏莺 郭韶梅 吴晓琴.痰液细胞分类及炎症因子测定在慢性阻塞性肺疾病治疗中的价值[J].实用中西医结合临床,2010,(2):3-4 |
| 痰液细胞分类及炎症因子测定在慢性阻塞性肺疾病治疗中的价值 |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 白细胞介素8 嗜酸性阳离子蛋白 |
| 英文关键词: Chronic Obstructive Pulmonary Disease Interleukin 8 Eosinophil Cationic Protein |
| 基金项目:江西省卫生厅支持课题（编号：20063006） |
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| 中文摘要: |
| 目的：探讨COPD急性加重期患者对糖皮质激素治疗有反应的决定因素。方法：采用常规理化和免疫荧光法，对40例COPD急性加重期患者治疗前后痰液中白细胞、嗜酸性粒细胞和嗜中性粒细胞进行计数；测定痰液中白细胞介素8 (IL-8) 、嗜酸性阳离子蛋白(ECP)水平。结果：痰液IL-8、ECP含量及嗜酸性粒细胞百分比与糖皮质激素治疗的效果呈正相关，相关系数分别为0.63、0.58、0.66。结论：痰液中嗜酸性粒细胞、IL-8及ECP增多的COPD急性加重期患者，可从糖皮质激素治疗中获益更多。 |
| 英文摘要: |
| Objective:To investigate the determinants of reactive for glucocorticoid in acute attacked patients with chronic obstructive pulmonary disease. Methods: Cell count, interleukin 8(IL-8) and eosinophil cationic protein (ECP) expression in septum were detected by routine physiochemical analysis or immunofluorescence assay in 40 cases with COPD in acute attack stage. Results: Positive correlation between effectiveness of glucocorticoid and concentration of IL-8, ECP, the number of eosinophils in septum were demonstrated with correlation coefficient of 0.63, 0.58, 0.66 respectively. Conclusions: Increases of eosinophils, IL-8 an ECP in septum indicate acute attacked patients with COPD could further benefit from glucocorticoid. |
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