| 黄晓英 裘英.新生儿缺氧缺血性脑病与血糖的临床研究[J].实用中西医结合临床,2009,(2):4-5 |
| 新生儿缺氧缺血性脑病与血糖的临床研究 |
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| DOI： |
| 中文关键词: 新生儿 脑缺氧 脑缺血 血糖 |
| 英文关键词: Infant Cerebral anoxia Cerebral ischemia Hyperglycemia |
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| 中文摘要: |
| 目的：探讨新生儿缺氧缺血性脑病(HIE)应激性血糖的发生情况及其临床意义。方法：采用美国强生公司生产的ONE TOUCH Ⅱ血糖仪及配套试纸对60例HIE患儿进行血糖监测，标本来自桡动脉血。结果：发现入院时治疗前高血糖19例(32%)，其中轻度无1例高血糖，中度3例(13%)，重度16例(89%)，中、重度相比差异有非常显著性(P <0.01)。重度HIE患儿治疗前血糖明显高于轻、中度，差异有非常显著性(P <0.01)；pH值和BE值均明显低于轻、中度(P <0.05，P <0.01)。且19例高血糖HIE患儿治疗前的血糖值与pH值、BE值均呈显著负相关(P <0.05，P <0.01)。治疗前血糖越高，病死率越高。结论：HIE患儿病情越重，应激反应越强烈，血糖升高越明显，脑细胞酸中毒越重，预后越差。因此，治疗前血糖测定可作为HIE患儿判断病情和预后的辅助指标。 |
| 英文摘要: |
| To study the incidence and the clinical significance of stressing hyperglycemia in newborn infants with hypoxic ischemic encephalopathy (HIE).Methods:The pretreated blood glucose (BG) of 60 cases with HIE was tested with One Touch Ⅱ glucose meter before treatment.Results:19 of the 60 cases (32%) had hyperglycemia,3 of them with moderate HIE and 16 with severe HIE, while no hyperglycemia was found in the mild ones. The incidence of hyperglycemia between the moderate cases and the severe cases was significant statistically (P <0.01).The pretreated BG in the severe cases was obviously higher(P <0.01), and the pH value (P <0.05) and BE negative value(P <0.01) were much lower than those in the mild and the moderate cases.The pretreated BG had significantly negative relation with the pH value (P <0.05) and BE (P <0.01) in the 19 cases of hyperglycemia.The higher pretreaed BG， the higher the mortality. Conclusion:The more severe the HIE is, the stronger stress will be; the higher BG, and more severe acidosis are the indicators of the poor prognosis . BG test before treatment is a secondary marker to evaluate the situation and prognosis of neonates with HIE. |
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