金泽 杨柏林 王长云.聚乙二醇4000联合莫沙比利治疗老年功能性便秘疗效分析[J].实用中西医结合临床,2008,(6):5-6 |
聚乙二醇4000联合莫沙比利治疗老年功能性便秘疗效分析 |
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DOI: |
中文关键词: 聚乙二醇4000 莫沙比利 老年功能性便秘 |
英文关键词: PEG4000 Mosapride Elderly functional constipations |
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中文摘要: |
目的:评价聚乙二醇4000联合莫沙比利治疗老年功能性便秘的疗效。方法:76例老年功能性便秘患者被随机分为两组。治疗组45例,口服聚乙二醇4000 10g,每日2次,莫沙比利5mg,每日3次;对照组31例,口服聚乙二醇4000 10g,每日2次,疗程4周。分别于第2周和第4周记录患者治疗情况,并观察药物不良反应。结果:治疗2周后,治疗组和对照组粪便性状恢复正常者为68.9% vs 63.3%;4周时治疗组和对照组粪便性状恢复正常为77.8% vs 63.3%,组间比较差异均无统计学意义。治疗2周时治疗组和对照组的总有效率为91.1% vs 86.7%(P =0.225),4周时总有效率为95.6% vs 90.0% (P =0.182);但 2周和4周显效率比较差异有统计学意义(68.9% vs 46.7%,P =0.046;84.4% vs 63.3%,P =0.001)。治疗期间,除对照组1例患者因自觉不适退出,两组均未发生明显不良反应。结论:聚乙二醇4000联合莫沙比利治疗老年功能性便秘安全、有效,其疗效明显优于单纯使用聚乙二醇4000。 |
英文摘要: |
Objective:To evaluate the efficacy of PEG4000 combined with Mosapride for the treatment of elderly functional constipations.Methods:76 older patients with functional constipation were included and allocated to therapeutic group (n=45) or the control group(n=31). All patients received PEG4000 10mg,twice a day;Therapeutic group also received Mosapride 5mg,three times per day. Therapeutic outcomes and side-effects were evaluated at fellow-up of 2 weeks and 4 weeks respectively.Results:Although there were no significant difference in total effective rate(91.1% vs 86.7%,95.6% vs 90.0%) and the hard pellety stools were changed to soft or thin stools (68.9% vs 63.3%,77.8% vs 63.3%) in patients, there were significant difference in the excellent rate between two groups (68.9% vs 46.7%,P =0.046;84.4% vs 63.3%,P =0.001)at fellow-up of 2 weeks and 4 weeks after treatment respectively.There were no side-effects during the treatment period.Conclusion:Use of PEG4000 combined with Mosapride treating elderly functional constipations is effective and safety. |
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