| 金泽 杨柏林 王长云.聚乙二醇4000联合莫沙比利治疗老年功能性便秘疗效分析[J].实用中西医结合临床,2008,(6):5-6 |
| 聚乙二醇4000联合莫沙比利治疗老年功能性便秘疗效分析 |
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| DOI： |
| 中文关键词: 聚乙二醇4000 莫沙比利 老年功能性便秘 |
| 英文关键词: PEG4000 Mosapride Elderly functional constipations |
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| 中文摘要: |
| 目的：评价聚乙二醇4000联合莫沙比利治疗老年功能性便秘的疗效。方法：76例老年功能性便秘患者被随机分为两组。治疗组45例，口服聚乙二醇4000 10g，每日2次，莫沙比利5mg，每日3次；对照组31例，口服聚乙二醇4000 10g，每日2次，疗程4周。分别于第2周和第4周记录患者治疗情况，并观察药物不良反应。结果：治疗2周后，治疗组和对照组粪便性状恢复正常者为68.9% vs 63.3%；4周时治疗组和对照组粪便性状恢复正常为77.8% vs 63.3%，组间比较差异均无统计学意义。治疗2周时治疗组和对照组的总有效率为91.1% vs 86.7%(P =0.225)，4周时总有效率为95.6% vs 90.0% (P =0.182)；但 2周和4周显效率比较差异有统计学意义(68.9% vs 46.7%，P =0.046；84.4% vs 63.3%，P =0.001)。治疗期间，除对照组1例患者因自觉不适退出，两组均未发生明显不良反应。结论：聚乙二醇4000联合莫沙比利治疗老年功能性便秘安全、有效，其疗效明显优于单纯使用聚乙二醇4000。 |
| 英文摘要: |
| Objective:To evaluate the efficacy of PEG4000 combined with Mosapride for the treatment of elderly functional constipations.Methods:76 older patients with functional constipation were included and allocated to therapeutic group (n=45) or the control group(n=31). All patients received PEG4000 10mg，twice a day；Therapeutic group also received Mosapride 5mg，three times per day. Therapeutic outcomes and side-effects were evaluated at fellow-up of 2 weeks and 4 weeks respectively.Results:Although there were no significant difference in total effective rate(91.1% vs 86.7%，95.6% vs 90.0%) and the hard pellety stools were changed to soft or thin stools (68.9% vs 63.3%,77.8% vs 63.3%) in patients, there were significant difference in the excellent rate between two groups (68.9% vs 46.7%,P =0.046;84.4% vs 63.3%,P =0.001）at fellow-up of 2 weeks and 4 weeks after treatment respectively.There were no side-effects during the treatment period.Conclusion:Use of PEG4000 combined with Mosapride treating elderly functional constipations is effective and safety. |
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