| 周龙 李瑶 熊国亮 雷建平.胸腔积液中粘蛋白1表达的临床意义[J].实用中西医结合临床,2008,(5):52-53 |
| 胸腔积液中粘蛋白1表达的临床意义 |
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| DOI： |
| 中文关键词: 癌 粘蛋白类 基因表达 胸腔积液 |
| 英文关键词: cancinoma mucins gene expression pleural effusion |
| 基金项目:江西省卫生厅资助课题（审批号20041143） |
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| 中文摘要: |
| 目的：评价MUC1mRNA在非小细胞肺癌患者和非肿瘤患者胸腔积液中表达的临床意义。方法：应用逆转录聚合酶链反应（RT-PCR）技术，对30例肺癌患者、20例非肿瘤患者的胸腔积液中的MUC1mRNA表达进行检测。结果：非肿瘤患者的胸腔积液中未检测到MUC1mRNA的表达。肺癌患者胸腔积液中MUC1mRNA的敏感性为30%（9/30），特异性为100%。胸腔积液中MUC1mRNA的表达与肺癌组织类型密切相关，P < 0.05；与患者年龄、性别、吸烟与否，肿瘤生长部位无明显相关，P > 0.05。结论：应用RT-PCR法检测肺癌患者胸腔积液中MUC1mRNA的表达，具有一定的临床参考价值。 |
| 英文摘要: |
| Objective: To evaluate the clininal significance of MUC1 mRNA expression in the pleural effusion of non-small cell lung cancer patients and non-cancer patients.Methods: Using RT-PCR to detect MUC1 mRNA expression in the pleural effusion in 30 patients with lung cancer, 20 patients with non-cancer .Results: MUC1 mRNA expression were found in the pleural effusion in 9/30 patients with lung cancer, and not found in non-cancer patients. Sensitivity of MUC1 mRNA expression were 30%(9/30), Specific of MUC1 mRNA expression were 100%. MUC1 mRNA expression in the pleural effusion was closely related to cell differentiation of cancer, P<0.05,but was not related to age, sex, smoking or not, site of tumor,P >0.05.Conclusions: MUC1 mRNA expression may be found with RT-PCR method in the pleural effusion of non-small cell lung cancer patients,it has a clinical reference value. |
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