| 王雪梅 袁小亮 俞银枝 宋军福 杨蓉美.配合小剂量不同疗程罗红霉素对下呼吸道绿脓杆菌感染的作用[J].实用中西医结合临床,2008,(5):8-9 |
| 配合小剂量不同疗程罗红霉素对下呼吸道绿脓杆菌感染的作用 |
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| DOI： |
| 中文关键词: 罗红霉素 绿脓杆菌 抗感染药 |
| 英文关键词: roxithromycin pseudomonas aeruginosa anti-infective |
| 基金项目:江西省卫生厅学术和技术带头人项目（项目编号045066） |
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| 中文摘要: |
| 目的：研究配合小剂量不同疗程罗红霉素对下呼吸道绿脓杆菌感染的作用。方法：将90例下呼吸道绿脓杆菌感染患者随机分为三组，对照组(n=30)根据药敏结果选用2种敏感抗生素联合抗绿脓杆菌，疗程3~4周，并治疗基础疾病；治疗B组(n=30)在对照组的基础上加用罗红霉素胶囊0.15g，2次/d，疗程1个月；治疗A组(n=30)在对照组的基础上加用罗红霉素胶囊0.15g，2次/d，疗程6个月。观察三组治疗前后临床疗效和细菌清除率。结果：临床总有效率对照组60.0%(18/30)，治疗B组83.3%(25/30)，治疗组A组93.3%(28/30)，细菌清除率对照组16.7%(5/30)，治疗B组40.0%(12/30)，治疗A组66.7%(20/30)，治疗B组临床总有效率和细菌清除率与对照组相比有显著差异(P <0.05)；治疗A组临床总有效率和细菌清除率与对照组相比有极显著差异(P <0.01)。结论：配合小剂量罗红霉素长疗程治疗下呼吸道绿脓杆菌感染疗效显著，且有利于抗生素对绿脓杆菌的清除。 |
| 英文摘要: |
| Objective: To investigate the effect of small dosage of roxithromycin on lower respiratory tract infection of pseudomonas aeruginosa. Methods: Ninety patients who infected pseudomonas aeruginosa in lower respiratory tract were divided into 3 groups randomly: therapy A group (n=30) , therapy B group (n=30) and control group(n=30). According to the result of pharmaceuticals sensitive ,we used a combination of two sensitive antibiotics for 3～4 weeks, and treated the basis diseases in 90 patients.At the same time we used roxithromycin(0.15g,twice a day)for 6 months in therapy A group and roxithromycin(0.15g,twice a day)for 1 months in therapy B group. Clinical effect and bacteria clearance before and after therapy were observed. Results: There were significant differences of clinical effect(P <0.01)and bacteria clearance(P <0.01)between therapy A group and control group. There were significant differences of clinical effect(P <0.05)and bacteria clearance(P <0.05)between therapy B group and control group. The clinical utility rates were 93.3% (28/30)、83.3%(25/30) and 60.0%(18/30) among therapy A group、therapy B group and control group, respectively.The bacteria clearance were 66.7% (20/30)、40.0%(12/30) and 16.7%(5/30) among therapy A group、therapy B group and control group,respectively. Conclusion: The effect of the long-term of therapy of small dosage roxithromyc on lower respiratory tract infection of pseudomonas aeruginosa is remarkable.And it is advantageous for clearance of pseudomonas aeruginosa in combination with antibiotic. |
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