王晓丽.维生素辅助治疗儿童癫痫56例疗效观察[J].实用中西医结合临床,2008,(4):9-10 |
维生素辅助治疗儿童癫痫56例疗效观察 |
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DOI: |
中文关键词: 癫痫 自由基 维生素E 维生素C |
英文关键词: Epilepsy free radical vitamin E vitamin C |
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中文摘要: |
目的:观察抗自由基药物(VE和VC)辅助治疗儿童癫痫的疗效。方法:癫痫患者56例,所有病例均符合国际抗癫痫联盟癫痫的诊断标准,随机分为传统抗癫痫药组(18例)、传统抗癫痫药+VE组(19例)、传统抗癫痫药+VC+VE组(19例),检测各组治疗前后静脉血中总抗氧化力(T-Aoc)及丙二醛(MDA)的平均水平。结果:(1)传统抗癫痫药+VE组静脉血中T-Aoc的平均水平较传统抗癫痫药组高,P <0.05;MDA的平均水平较传统抗癫痫药组低,P <0.05。(2)传统抗癫痫药+VC+VE组T-Aoc的平均水平较传统抗癫痫药+VE组高,但P >0.05,无统计学意义;MDA的平均水平较传统抗癫痫药+VE组低,P <0.05。(3)传统抗癫痫药+VC+VE组、传统抗癫痫药+VE组、传统抗癫痫药组治疗后的总有效率分别为68.4%、63.2%、55.6%。结论:对癫痫患儿加用抗自由基药物(VE和VC)作为辅助治疗,在血液指标与疗效方面可能优于未加者。VE、VC联合应用能起到协同效应,二者联合可能增强了抗氧化效果与抗癫痫作用。 |
英文摘要: |
Objective: To investigate the relationship between free radical and epilepsy, observe the effect of antioxidant(vitamin E and vitamin C).Methods: The epilepsy group consists of 56 partial epilepsy cases, diagnosed according the classification of the International League Against Epilepsy. The epilepsy group was divided randomly into three sub-groups: traditional anticonvulsant group(18 cases),traditional anticonvulsant drug group plus vitamin E(19 cases),traditional anticonvulsant drug group plus vitamin E and C(19 cases).Vein plasma total antioxidant capacity(T-Aoc) and malondialdehyde(MDA)were measured in three groups before and after treatment. Results :The T-Aoc level was increased in add-on vitamin E/vitamin C groups and higher than in traditional anticonvulsant group. The MDA level was decreased in add-on vitamin E/vitamin C groups (P <0.05).Compared to traditional anticonvulsant group, seizure frequency was slightly decreased in add-on vitamin E group, and in add-on vitamin E and vitamin C group, the effective rate was 55.6%,63.2%and 68.4%separately.Conclusion: Add-on antioxidant(vitamin E/vitamin C)therapy showed difference both in laboratory test and clinical seizure frequency.Vitamin E worked in coordination with vitamin C,when used together, their antioxidant and anticonvulsant effect may be strengthened. |
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