| 刘思海 冯雯 朱瑞霞 付正传.斑蝥酸钠维生素B6注射液联合草酸铂与替加氟持续泵入治疗晚期胃癌的比较研究[J].实用中西医结合临床,2008,(4):3-4,17 |
| 斑蝥酸钠维生素B6注射液联合草酸铂与替加氟持续泵入治疗晚期胃癌的比较研究 |
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| 中文关键词: 肿瘤学 胃癌 辅助化疗 疗效 替加氟 草酸铂 PICC 斑蝥酸钠 |
| 英文关键词: Oncology gastric carcinoma chemotherapy oxaliplatin tegafur PICC Disodium Cantharidinate |
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| 中文摘要: |
| 目的：探讨斑蝥酸钠维生素B6注射液联合草酸铂与替加氟持续泵入治疗晚期胃癌的效果。方法：64 例晚期胃癌患者分别接受方案A(32例)、方案B(32例)治疗。方案A（A组）：替加氟800mg/m2,CIV(24h),d1~5；LV 200mg/m2,ivgtt(2h),d1~5；L-OHP 85mg/m2，ivgtt(2h)，d1；斑蝥酸钠维生素B6注射液50mL，d1~28。方案B（B组）：替加氟800mg/m2,CIV(24h),d1~5；LV 200mg/m2,ivgtt(2h),d1~5；L-OHP 85mg/m2，ivgtt(2h)，d1；28d为1个周期。结果：方案A：CR7例，PR16例，有效率71.9%；方案B：CR5例，PR16例，有效率65.6%；方案A优于方案B，差异无显著性意义(?字2=0.5909, P =0.59) 。A组患者出现血中白细胞及血小板下降、血清尿素氮及转氨酶升高的数量明显少于B组，A组患者Karnofsky评分明显高于B组患者、精神状态明显好于B组患者、消化道反应明显轻于B组患者，且A组患者在疼痛缓解、食欲及睡眠改善、体重增加等方面均优于B组（P <0.05）。两种方案的不良反应均易于接受。结论：斑蝥酸钠维生素B6注射液联合草酸铂与替加氟持续泵入治疗晚期胃癌具有协同作用，并且具有提高接受化疗患者的生活质量、减轻化疗药物对患者的毒副作用、提高患者对化疗药物的耐受作用，可以作为晚期胃癌安全有效的治疗方案。 |
| 英文摘要: |
| Objective:To study the effect of l Disodium Cantharidinate and Vitamin B6 Injection combined with oxaliplatin and tegafur in the treatment of advanced gastric cancer.Methods:64 cases advanced gastric cancer were treated with regimenA,regimenB.RegimenA:tegafur800mg/m2,CIV(24h),d1~5;LV200mg/m2,ivgtt(2h),d1~5；L-OHP135mg/m2，ivgtt(2h)，d1. Disodium Cantharidinate and Vitamin B6 Injection 50mL,d1~28.RegimenB：tegafur800mg/m2,CIV(24h),d1~5;LV200mg/m2,ivgtt(2h),d1~5；L-OHP135mg/m2，ivgtt(2h)，d1Regimen A and B were repeated every 28 days.Results:There were 5 CR,16 cases in the regimen B; 4 CR,16 PR cases in the regimen A; 65.6% and 71.9% respectively.The difference did not reach the level of statistical significance (?字2=0.5909, P=0.59).The adverse effects of the two regimens were mild.Conclusion:The study of Disodium Cantharidinate and Vitamin B6 Injection combined with oxaliplatin and tegafur in the treatment of advanced gastric cancer is safe and effective. |
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